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Theorem. For all \\(a,b\\in\\mathbb R\\) and \\(u\\in C_0^{\\infty}(\\mathbb R^N\\setminus\\{0\\})\\) one has   \\[  \\biggl[(n-2-\\gamma)\\int_{\\mathbb R^N}\\frac{|\\nabla u|^2}{|x|^{\\gamma}}\\,dx+ 2\\gamma\\int_{\\mathbb R^N}\\frac{(x\\cdot\\nabla u)^2}{|x|^{\\gamma+2}}\\,dx\\biggr]^2\\leq 4\\biggl(\\int_{\\mathbb R^N}\\frac{|\\Delta u|^2}{|x|^{2b}}\\,dx\\biggr)\\biggl(\\int_{\\mathbb R^N}\\frac{|\\nabla u|^2}{|x|^{2a}}\\,dx\\biggr)  \\]   where \\(\\gamma:=a+b+1\\). In addition, if \\(\\gamma\\leq n-2\\), then   \\[  \\biggl|\\frac{N+a+b-1}{2}\\biggr|\\int_{\\mathbb R^N}\\frac{|\\nabla u|^2}{|x|^{a+b+1}}\\,dx\\leq \\biggl(\\int_{\\mathbb R^N}\\frac{|\\Delta u|^2}{|x|^{2b}}\\,dx\\biggr)^{1/2} \\biggl(\\int_{\\mathbb R^N}\\frac{|\\nabla u|^2}{|x|^{2a}} \\,dx\\biggr)^{1/2},  \\]   where the constant \\(|\\frac{N+a+b-1}{2}|\\) is 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