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Such assumptions include very rapid kinetics for nonspecific binding and the absence of multiple specific receptors or subtypes. Computer simulations, based on an exact analytical solution of the relevant differential equations, indicate the numerical errors that can arise when the assumptions are invalid.    We propose a four-compartment model which requires fewer assumptions. A simple relationship is derived for expressing the microscopic rate constants of either the three- or four-compartment model as explicit functions of the experimentally-observed macroscopic rate constants. This could eliminate the need for time-consuming, iterative, non-linear, curve-fitting approaches and numerical integration. 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