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The regression function f is assumed to belong to the class  \\[  F_ 0=\\{f | \\quad | f^{(h+1)}(x)| \\leq \\epsilon,\\quad x_ 0<x<\\infty \\},  \\]  where \\(\\epsilon >0\\) and \\(0>x_ 0\\in X^ c\\) are given numbers. An n point experimental design \\(\\xi\\) with support \\(x_ 1,x_ 2,...,x_ r\\in X\\) is defined to be a probability measure on X putting mass \\(m_ i>0\\) at \\(x_ i\\). The design is exact if \\(n_ i=n m_ i\\) are integers and approximate otherwise. An estimator of \\(f(x_ 0)\\) of the form \\(\\hat f= \\sum^{r}_{i=1}a_ i\\bar Y(x_ i)\\), based on \\(\\xi\\), where \\(\\bar Y(x_ i)\\) is the mean of the \\(n_ i\\) observations at \\(x_ i\\), is to be used to extrapolate the value of f at \\(x_ 0\\). 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