{"entities":{"Q1117155":{"pageid":1127904,"ns":120,"title":"Item:Q1117155","lastrevid":66163434,"modified":"2026-04-12T07:58:25Z","type":"item","id":"Q1117155","labels":{"en":{"language":"en","value":"Models for dose intensity"}},"descriptions":{"en":{"language":"en","value":"scientific article; zbMATH DE number 4091240"}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"fd5912e4dab4b881a8eb0eb27e7893fef55176ad","datavalue":{"value":{"entity-type":"item","numeric-id":56887,"id":"Q56887"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1117155$3E66E1CC-B063-4825-BFAB-E02489632643","rank":"normal"}],"P159":[{"mainsnak":{"snaktype":"value","property":"P159","hash":"efb6e9b6985b1f420a82608fea2acb673ae468f2","datavalue":{"value":{"text":"Models for dose intensity","language":"en"},"type":"monolingualtext"},"datatype":"monolingualtext"},"type":"statement","id":"Q1117155$193450CE-322D-4675-84C9-3AD50413CBF9","rank":"normal"}],"P225":[{"mainsnak":{"snaktype":"value","property":"P225","hash":"d465c7932c9eb2644cf0313554208278799f41b6","datavalue":{"value":"0666.92002","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1117155$DD137A67-0C16-4504-BB91-254B66349EB9","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"47abd75fb3b1f5a0124d2b1aa0384675ac3a212a","datavalue":{"value":"10.1016/0025-5564(88)90007-7","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1117155$36C15BE2-4FC0-4775-8B99-1F0F47596A2C","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"0d3f7f9e1c4398352572b638a8cd521418e82aff","datavalue":{"value":{"entity-type":"item","numeric-id":1064976,"id":"Q1064976"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1117155$A2EC4B4E-4C9C-4EF1-B8EC-FF8B3B302A3C","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"170bd6a0cf7fd29a7e59027956e3e1ba075b373d","datavalue":{"value":{"entity-type":"item","numeric-id":1117154,"id":"Q1117154"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1117155$6F1DE911-06F3-4FA8-965C-6B2149797F0B","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"0f4ddf528c5725927622a42eaecbc6fbd9a803fc","datavalue":{"value":{"entity-type":"item","numeric-id":1064977,"id":"Q1064977"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1117155$F7F4E46F-AF16-4155-AB44-FE78FBD0364A","rank":"normal"}],"P200":[{"mainsnak":{"snaktype":"value","property":"P200","hash":"80ca2db0e08c59d0ca007bc992ad8905c2022207","datavalue":{"value":{"entity-type":"item","numeric-id":64191,"id":"Q64191"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1117155$62CEBFE9-CBA7-4BBD-9141-8BB7AFAE5278","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"31a1937240ca4a323604b4728c31d242b5596d7c","datavalue":{"value":{"time":"+1988-00-00T00:00:00Z","timezone":0,"before":0,"after":0,"precision":9,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q1117155$0EF3C015-86F1-4A5C-878D-0095EAC9B925","rank":"normal"}],"P1448":[{"mainsnak":{"snaktype":"value","property":"P1448","hash":"4138c9b8e9f9a0274801c87d6c3e4ed7a01fa532","datavalue":{"value":"The authors introduce a concept of a time-dependent dose intensity function as a determinant of the therapeutic outcome of chemotherapy in cancer treatment related to tumor size, generalizing a proposal by Hryniak [\\textit{W. M. Hryniak} and \\textit{M. Bush}, The importance of dose intensity in the chemotherapy of metastatic breast cancer J. Clin. Oncol. 2, 1281-1288 (1984)]. The number N(t) of tumor cells at time t is modelled as  \\[  d(\\ln N(t))/dt=h_ 1(N(t))[1-h_ 2(C(t)]  \\]  where \\(h_ 1\\) and \\(h_ 2\\) are integrable functions referred to growth and kill, and where c(t) is the drug concentration at time t; \\(N(0)=1\\), \\(h_ 1(N)>0\\), and \\(h_ 2(0)=0\\). The dose intensity for the interval (t',t) is defined as  \\[  I(t',t)=[\\int^{t}_{t'}h_ 2(C(u))du]/(t-t')  \\]  represnting a mean kill over that interval. The possible range of application is discussed and illustrated by two examples where \\(h_ 2=k C\\). For chemotherapy administred as a series of cycles repeated a fixed number of times at regular intervals, a ranking of protocols by their dose intensity function is defined and the case \\(h_ 2(C(t))=k C(t)\\) is considered. The model is finally extended to the development of drug resistance by introducing the probability \\(P_ 0(t)\\) that there are no resistant cells at time t as solution of  \\[  d(\\ln P_ 0(t))/dt=-\\alpha h_ 1(N(t))N(t).  \\]  Calculation of the conditional probability \\(P(t',t)=P_ 0(t)/P_ 0(t')\\) that resistance develops for the first time in the inteval [t',t] shows that protocols can then no longer be ranked by the dose intensity alone but have to be complemented by information from the tumor's growth.","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$2D439875-FC6B-4F1E-A54A-1EBF6177D5D5","rank":"normal"}],"P226":[{"mainsnak":{"snaktype":"value","property":"P226","hash":"e27beffea4779e8a96e7c5961e8cc7879483d808","datavalue":{"value":"92C50","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1117155$D64F63C8-97E5-4662-9128-C21F7A2D450D","rank":"normal"}],"P1451":[{"mainsnak":{"snaktype":"value","property":"P1451","hash":"ea64265de717317133e38bfe5d7c69494dae5950","datavalue":{"value":"4091240","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1117155$955A4969-87D5-4B5F-9CEC-F115D49505FA","rank":"normal"}],"P1450":[{"mainsnak":{"snaktype":"value","property":"P1450","hash":"f86887882de193c98f9946d96b9ccf7ecfb92587","datavalue":{"value":"deterministic growth model","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$67B9AC49-D1E8-4595-92EB-A9E8F1D685DC","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"de55c689cab1b3df06891eea52b7cff1e8c92e0e","datavalue":{"value":"tumor resistance","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$19310401-CA47-4D26-B8AD-ED1DF1DA973C","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"5d251fc6dbfee4fac39ceb55c4781cd7809e0ae5","datavalue":{"value":"ranking of treatment protocols","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$AF6CA52C-CFC2-4DBD-BF48-70ED8C13535D","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"fc02a54faf14ac6bfe9bc1b2eb976cd8c3ac5f43","datavalue":{"value":"time-dependent dose intensity function","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$96337B0A-F9B5-41E0-B89A-10423423F856","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"989c743fb94f6452a98afaeb2aa743eafed75420","datavalue":{"value":"chemotherapy","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$CEFA1992-468A-443C-B65C-DF519E2D9ACE","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"3190668f1951df21ae2183ad3c2663d88ddca1ae","datavalue":{"value":"cancer treatment","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$B2B08A93-1624-48E4-B043-216F216D93B5","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"e7b02044616542691a174bb41e9eb80a28ccf46d","datavalue":{"value":"tumor size","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$4034A26C-CF6C-4A00-A214-92896C53C6E8","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"1b816843733d3391bb514b52983c71a8ff646ddd","datavalue":{"value":"drug concentration","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$5FF9E938-4FA8-402A-90DA-93758A01E1C4","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"5099bec998e69be611b6e6f924c925d7843f6805","datavalue":{"value":"drug resistance","type":"string"},"datatype":"string"},"type":"statement","id":"Q1117155$F89B57CE-801F-4966-91EB-27D196C6A08E","rank":"normal"}],"P1447":[{"mainsnak":{"snaktype":"value","property":"P1447","hash":"d563270692234f52fa9fbe848003e44963d4183a","datavalue":{"value":{"entity-type":"item","numeric-id":208210,"id":"Q208210"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1117155$9B7D1F36-1FD7-44B8-AA86-2C4F324C3859","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"57f7fea50d2ce1b39b695c4a1313582eed405e38","datavalue":{"value":{"entity-type":"item","numeric-id":5976449,"id":"Q5976449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1117155$7E81673F-8A8B-46BF-8128-EF84EE8D785E","rank":"normal"}],"P205":[{"mainsnak":{"snaktype":"value","property":"P205","hash":"490252f1d9cdf44508b43ccb415e042d939b8ddb","datavalue":{"value":"https://doi.org/10.1016/0025-5564(88)90007-7","type":"string"},"datatype":"url"},"type":"statement","id":"Q1117155$5C5FD4B8-6377-4900-8F47-85CC0D7AD6CC","rank":"normal"}],"P388":[{"mainsnak":{"snaktype":"value","property":"P388","hash":"6f72c76e53ab33ededcd8352c137613c80e8d64c","datavalue":{"value":"W1970665628","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1117155$87AEDED1-4809-4902-A79C-779649E78831","rank":"normal"}],"P223":[{"mainsnak":{"snaktype":"value","property":"P223","hash":"36496e63784a227663f18027e8c4e6a374ae6c83","datavalue":{"value":{"entity-type":"item","numeric-id":1064978,"id":"Q1064978"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1117155$0453B87F-99C9-49C9-AAB4-6084D12709EE","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"78710bc475a13c38359361a15cadb70a136ca3ed","datavalue":{"value":{"entity-type":"item","numeric-id":1066841,"id":"Q1066841"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1117155$A25E08B2-39F8-479A-8EAC-11F554E4243C","rank":"normal"}],"P1643":[{"mainsnak":{"snaktype":"value","property":"P1643","hash":"dd696184c8ebe29251dcbfb6834be257256591e2","datavalue":{"value":{"entity-type":"item","numeric-id":1370446,"id":"Q1370446"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"15118e9489e2db3f34cf760545c45d61993e57db","datavalue":{"value":{"amount":"+0.7995951771736145","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1117155$A3BC134F-A05F-47B4-806D-87E5B3761FA0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"edfc1a743e684d35e86f80436de9ab008185e977","datavalue":{"value":{"entity-type":"item","numeric-id":1804871,"id":"Q1804871"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"eeeff35b6d36aa93c55821e36652b72f4e55fdf7","datavalue":{"value":{"amount":"+0.7643279433250427","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1117155$64F0616C-99B4-4EAE-B145-82C98F9163B0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"f11f3eda92f94da0692de7d83ddf015d3aa59495","datavalue":{"value":{"entity-type":"item","numeric-id":1262234,"id":"Q1262234"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"b62f37c5e3b171c0432473c77420662ccc58be8d","datavalue":{"value":{"amount":"+0.7635392546653748","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1117155$2D07EBF1-DAAF-4076-A956-2E73ED18BFA4","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"fd74dce3172c7540a7e0aef2beba4feff63a0b38","datavalue":{"value":{"entity-type":"item","numeric-id":4375856,"id":"Q4375856"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"7845d1e843acef28d0adb413fc8ef3a8b677186d","datavalue":{"value":{"amount":"+0.7626501321792603","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1117155$2464CF90-CB8F-41CF-852A-FC4DDE2BF1EB","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"b0285363b1b96d6d74d09f16619531d9e3f7f1ed","datavalue":{"value":{"entity-type":"item","numeric-id":2340517,"id":"Q2340517"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"7845d1e843acef28d0adb413fc8ef3a8b677186d","datavalue":{"value":{"amount":"+0.7626501321792603","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1117155$56B8F9E7-F639-4019-B05B-7714A8E30225","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"Models for dose intensity","badges":[],"url":"https://portal.mardi4nfdi.de/wiki/Models_for_dose_intensity"}}}}}