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In particular it is shown that any \\(n\\)-vertex triangulation of a 4-dimensional Eulerian manifold \\(M\\) satisfying the equality \\(\\binom{n-4}{3} = 10(_{\\mathcal X}(M)-2)\\) induces a block design \\(S_{2n-8}(2,5,n)\\) without repeated blocks. (Here \\(_{\\mathcal X}\\) denotes the Euler characteristic.) On the other hand, a given block design \\(S_{2n-8}(2,5,n)\\) without repeated blocks induces an Eulerian 4-manifold satisfying the equality \\(\\binom{n-4}{3}= 10(_{\\mathcal X}(M)-2)\\) provided that each of the 4-tuples occurs in exactly two of the blocks. Necessary conditions for this family imply that the first interesting cases are \\(S_4(2,5,6)\\), \\(S_{10}(2,5,9)\\), \\(S_{12}(2,5,10)\\), \\(S_{20}(2,5,14)\\) and \\(S_{24}(2,5,16)\\). The existence of 3-neighborly combinatorial 4-manifolds with \\(n \\leq 13\\) vertices was studied by \\textit{W. K\u00fchnel} and \\textit{G. Lassmann} [The unique 3-neighborly 4-manifold with few vertices, J. Comb. Theory Ser. A 35, 173-184 (1983; Zbl 0526.52008)]. For the next case (\\(n=14\\)) the following is shown: (1) there is no combinatorial 4-manifold with 14 vertices and \\(\\binom{14}{3}\\) triangles admitting a vertex transitive action of \\(Z_{14}\\); (2) however there is a unique triangulated Eulerian 4-manifold with the other properties in (1); (3) this implies the existence of a cyclic design \\(S_{20}(2,5,14)\\) without repeated blocks and with the extra condition that 4-tuples occur in exactly two blocks if they occur at all. The authors raise the question of whether the necessary condition \\(n(n-1)(n-4) \\equiv 0 \\pmod{20}\\) is also sufficient for the existence of an \\(n\\)-vertex triangulation of an Eulerian 4-manifold \\(M\\) satisfying \\(\\binom{n-4}{3}= 10(_{\\mathcal X}(M)-2)\\). Since the necessary conditions are known to be sufficient for the existence of an \\(S_{2n-8}(2,5,n)\\), the remaining question is whether repeated blocks can be avoided and whether one can always guarantee the extra condition that 4-tuples occur in exactly two blocks if they occur at all. The paper concludes with a summary of results for higher dimensional Eulerian \\(2k\\)-manifolds, and some open 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