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For instance, the author considers the variational problem:  \\[ S(p,q,\\alpha,\\beta,n)=\\inf \\Biggl[\\int_{\\mathbb{R}^n}|\\nabla u|^p| x|^{p\\alpha} dx : u \\in W_{\\alpha,\\beta}^{1,p}(\\mathbb{R}^n),\\| u\\|_{L_\\beta^q}= 1\\Biggr]. \\]  The invariance of \\(\\mathbb{R}^n\\) by the group of dilatations may cause the loss of compactness, so the existence of extremals essentially depends on parameters. The author proves that under suitable relations between the parameters the extremals exist and this permits to get the best constant in the Sobolev inequality:  \\[ \\int_{\\mathbb{R}^n}|\\nabla u|^p| x|^{p\\alpha} dx\\geq S(p,q,\\alpha,\\beta,n) \\Biggl(\\int_{\\mathbb{R}^n}| u|^q| x|^{q\\beta} dx\\Biggr)^{p/q}, \\]  where \\(u\\) is any function in \\(C_0^1(\\mathbb{R}^n)\\). The obtained theorems generalize some earlier results of Talenti, Maz'ya and 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