{"entities":{"Q1614842":{"pageid":1625582,"ns":120,"title":"Item:Q1614842","lastrevid":70979292,"modified":"2026-04-13T18:39:14Z","type":"item","id":"Q1614842","labels":{"en":{"language":"en","value":"The shared frailty model and the power for heterogeneity tests in multicenter trials."}},"descriptions":{"en":{"language":"en","value":"scientific article; zbMATH DE number 1797836"}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"fd5912e4dab4b881a8eb0eb27e7893fef55176ad","datavalue":{"value":{"entity-type":"item","numeric-id":56887,"id":"Q56887"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$561C85EC-1F17-4298-B2AC-F54F67656AF0","rank":"normal"}],"P159":[{"mainsnak":{"snaktype":"value","property":"P159","hash":"076b73067b63d30b0a9d0e6a7707ec51472c9e93","datavalue":{"value":{"text":"The shared frailty model and the power for heterogeneity tests in multicenter trials.","language":"en"},"type":"monolingualtext"},"datatype":"monolingualtext"},"type":"statement","id":"Q1614842$0BF6D5BD-14CD-42BF-9B05-CE12B12AB4C6","rank":"normal"}],"P225":[{"mainsnak":{"snaktype":"value","property":"P225","hash":"1c0dc28308377d5f60e30c8c57253b2297a18585","datavalue":{"value":"1180.62139","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1614842$FC9B6500-992F-4486-B800-155AE8B976BA","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"4fbd34e6af8682339c347521efe85e4eb4e903db","datavalue":{"value":"10.1016/S0167-9473(02)00057-9","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1614842$EF55D7A3-A65F-41D0-95A1-EA15C63BD7F9","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"4cd9b5cde5a5dff4d6a2b8e103a85bb536634ac6","datavalue":{"value":{"entity-type":"item","numeric-id":840747,"id":"Q840747"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$09E406C3-7B4F-424F-9AA3-5ED98EA112BB","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"4fca60b1f14a078a97395a69349278f15b477655","datavalue":{"value":{"entity-type":"item","numeric-id":169456,"id":"Q169456"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$77407953-DE4B-4D25-86CA-5E8F07AFAC57","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"8f465102fcd05a7a82ae499a6c79311b0e973ebe","datavalue":{"value":{"entity-type":"item","numeric-id":1614841,"id":"Q1614841"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$BACD916C-0E2C-49E5-88FD-0D1C5FFC6AE1","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"568229e9c65383d986a4a295e61fa2266b0c5d3c","datavalue":{"value":{"entity-type":"item","numeric-id":825293,"id":"Q825293"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$3D796784-9574-4C2F-BADD-E8CEC88D4776","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"bd9c727b57954d9ca3071851d1f756d7ac2e8098","datavalue":{"value":{"entity-type":"item","numeric-id":946206,"id":"Q946206"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$428C7EED-4E60-438C-8AB5-2E34BACF6C25","rank":"normal"}],"P200":[{"mainsnak":{"snaktype":"value","property":"P200","hash":"a3fc06e9fbf322a9f6c41af825f926da65974fb3","datavalue":{"value":{"entity-type":"item","numeric-id":196900,"id":"Q196900"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$7E57A666-2F12-4700-ACF3-5016F9258997","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"b1499fc920b3ce6e459673c257729080eb3a13dc","datavalue":{"value":{"time":"+2002-09-09T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q1614842$10D5CE0D-078B-40FD-ADE0-3DDF3AF847DC","rank":"normal"}],"P1448":[{"mainsnak":{"snaktype":"value","property":"P1448","hash":"290c228b632ec37c81494ccb00bce4a76e425452","datavalue":{"value":"Heterogeneity between centers in multicenter trials with time to event outcome can be modeled by the frailty proportional hazards model. The majority of the different approaches that have been used to fit frailty models assume either the gamma or the lognormal frailty density and are based on similar log likelihood expressions. These approaches are briefly reviewed and their specific features described; simulations further demonstrate that the different techniques lead to virtually the same estimates for the heterogeneity parameter. An important issue is the relationship between the size of a multicenter trial, in terms of number of centers and number of patients per center, and the bias and the spread of estimates of the heterogeneity parameter around its true value. Based on simulation results (restricted to constant hazard rate and the gamma frailty density), it becomes clear how the number of centers and the number of patients per center influence the quality of the estimates in the particular setting of breast cancer clinical trials. This insight is important in treatment outcome research, where one tries to relate differences with respect to clinical practice to differences in outcome in the various centers.","type":"string"},"datatype":"string"},"type":"statement","id":"Q1614842$2BF6779C-F62E-47BB-8636-54041FB8CC80","rank":"normal"}],"P226":[{"mainsnak":{"snaktype":"value","property":"P226","hash":"948dd30fa7aee33f4ba6adbce243dba18e816c1c","datavalue":{"value":"62N02","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1614842$CA39805D-CE78-4257-8E33-B7790261ECC5","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"f6e19b5dbba890acf228001be2867e77dd5af971","datavalue":{"value":"62N03","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1614842$D9B42B35-B7D7-4E90-8C73-CC140C2D8306","rank":"normal"}],"P1451":[{"mainsnak":{"snaktype":"value","property":"P1451","hash":"4818cd81502d8b4dfb29594f967ae0cff93b47a9","datavalue":{"value":"1797836","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1614842$10317920-7297-4B15-9340-E6AFB6AD5CE2","rank":"normal"}],"P1450":[{"mainsnak":{"snaktype":"value","property":"P1450","hash":"c21b1e4e7205b8f7830d823ec0ca0216c0ad76b1","datavalue":{"value":"Frailty model","type":"string"},"datatype":"string"},"type":"statement","id":"Q1614842$DA3E0498-9232-4163-88B5-1FC6A0C4A7DB","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"2e67a44167492cc8a9eb88c728a4ddfd46a1b215","datavalue":{"value":"Treatment outcome","type":"string"},"datatype":"string"},"type":"statement","id":"Q1614842$ACD46E92-A1D8-4422-80FB-56AEA412243B","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"0a65fba0a9d5b4549e1cd5736d761dd1670cacd3","datavalue":{"value":"Multicenter trial","type":"string"},"datatype":"string"},"type":"statement","id":"Q1614842$A03C0BE2-97BA-4953-A021-B7ADA40EB174","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"e6bd8768bef4e832f96736fc80a17ca4c6f61f40","datavalue":{"value":"EM algorithm","type":"string"},"datatype":"string"},"type":"statement","id":"Q1614842$FD852AFC-3439-49B5-B26E-405A8141C9A0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"1af214ba24b3510928336d84dc097a728bd4411d","datavalue":{"value":"Penalized likelihood","type":"string"},"datatype":"string"},"type":"statement","id":"Q1614842$72E693AB-9A5F-4E96-B658-C09420AE10A4","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"5b3ac48782cf24bf91a5b5d0d63a02dd252c191d","datavalue":{"value":"REML","type":"string"},"datatype":"string"},"type":"statement","id":"Q1614842$07FFBE52-868A-4F38-8D96-2E76C320BB5D","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"57f7fea50d2ce1b39b695c4a1313582eed405e38","datavalue":{"value":{"entity-type":"item","numeric-id":5976449,"id":"Q5976449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$160CF77A-34E1-4940-B407-F61E606AAC1B","rank":"normal"}],"P223":[{"mainsnak":{"snaktype":"value","property":"P223","hash":"14427ce799bc23f96abfda6508e669c24fde6385","datavalue":{"value":{"entity-type":"item","numeric-id":5919854,"id":"Q5919854"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$47A6C6D6-85E9-4FDF-BF8A-D6F7DEE5DD07","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"f07818b634e459fdfbede08defa40c8e8ef26894","datavalue":{"value":{"entity-type":"item","numeric-id":4139463,"id":"Q4139463"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$F66C5D8B-7090-4071-B5E4-BE66BF4D14A9","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"00980a01842f0d7a15eff0ffb744b2a703ce2430","datavalue":{"value":{"entity-type":"item","numeric-id":1355337,"id":"Q1355337"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$EAE8728B-42D7-431A-BFBE-1BF2CB9EB78B","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"38dba74cf1757fc0cbb256c64805c169ff943c4e","datavalue":{"value":{"entity-type":"item","numeric-id":1339688,"id":"Q1339688"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$9F1B08AB-E7E1-4928-8F88-169F95CF8813","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"39f5853a1c135d6c0455966c2feebfa3c879a2de","datavalue":{"value":{"entity-type":"item","numeric-id":1895353,"id":"Q1895353"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$0D7C56FF-7B13-4C43-B3C1-F940865DB121","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"a55c508fa6d4d04c6eaeb817cc026dd88c52d4f0","datavalue":{"value":{"entity-type":"item","numeric-id":4012692,"id":"Q4012692"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$79C8F82D-2F0D-476F-986E-3C7D3A098C24","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"6377d2c1ef72647cc19dfadb19bbd6d09890b6fb","datavalue":{"value":{"entity-type":"item","numeric-id":1807069,"id":"Q1807069"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$F4055BC9-8C0B-434A-9C36-4DDE189D3F0C","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"645639698e8969506f500c8061e0fff501230389","datavalue":{"value":{"entity-type":"item","numeric-id":3780259,"id":"Q3780259"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$D5BE6B59-7FAB-4171-BD43-BB097F3BDE6E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"96201b2fb79c5f1958f49adca566fdaa162d4d07","datavalue":{"value":{"entity-type":"item","numeric-id":4844297,"id":"Q4844297"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$9789A42E-BA88-4246-8273-BEA0271D493E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"61dbe8b229cfdccffc09b1da9e05fdcb759c1bcc","datavalue":{"value":{"entity-type":"item","numeric-id":1582803,"id":"Q1582803"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1614842$8F4B8E33-03E8-45B6-B3FC-7BEBFA27A93E","rank":"normal"}],"P1643":[{"mainsnak":{"snaktype":"value","property":"P1643","hash":"b574005a1fe61029231a553ac5ad66a70f250a80","datavalue":{"value":{"entity-type":"item","numeric-id":5424143,"id":"Q5424143"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"62aaabdb38c6ab00dd6b71bf07d62b7d80ccde58","datavalue":{"value":{"amount":"+0.81663978099823","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1614842$1E5EC60F-55DF-4B3C-B8FF-A93492DF2FCC","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"ed99de980bb3916d4c5c1fb9fbb7202101a55785","datavalue":{"value":{"entity-type":"item","numeric-id":5122553,"id":"Q5122553"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"532d4292a82db2cdba1546beda8d79f77334c608","datavalue":{"value":{"amount":"+0.7711038589477539","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1614842$FF058979-FFE5-43BE-84E3-0CDF9C552C33","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"eb346d38b9aaeea2cc49c32d1266ded40305e6ae","datavalue":{"value":{"entity-type":"item","numeric-id":3632577,"id":"Q3632577"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"1c846bbc3b405a38ad87f309899a026c13888297","datavalue":{"value":{"amount":"+0.7667514681816101","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1614842$800A7702-84A7-4CAF-8C7A-7D5EEA3F22A0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"1740cf5e0423506e1a336f86eb05320ad1dc9e09","datavalue":{"value":{"entity-type":"item","numeric-id":3078933,"id":"Q3078933"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"df5675f8943a5ade9e1a1bfe403524406d82ca1f","datavalue":{"value":{"amount":"+0.7656689882278442","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1614842$571708B1-6DD5-4C0E-BE1F-361AA2A1EED7","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"87a6c2d2f026f9568adff89b141330d2998f011a","datavalue":{"value":{"entity-type":"item","numeric-id":2397980,"id":"Q2397980"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"80b5b47bd758cfee31ae7b5b3ff1fdbc693e7a1f","datavalue":{"value":{"amount":"+0.761238694190979","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1614842$7A4D43B3-E6FD-415B-8149-18275E2F6FE6","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"The shared frailty model and the power for heterogeneity tests in multicenter trials.","badges":[],"url":"https://portal.mardi4nfdi.de/wiki/The_shared_frailty_model_and_the_power_for_heterogeneity_tests_in_multicenter_trials."}}}}}