{"entities":{"Q1634707":{"pageid":1645448,"ns":120,"title":"Item:Q1634707","lastrevid":57412002,"modified":"2026-03-30T20:40:35Z","type":"item","id":"Q1634707","labels":{"en":{"language":"en","value":"Recurrent neural network-based model predictive control for continuous pharmaceutical manufacturing"}},"descriptions":{"en":{"language":"en","value":"scientific article; zbMATH DE number 6994845"}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"fd5912e4dab4b881a8eb0eb27e7893fef55176ad","datavalue":{"value":{"entity-type":"item","numeric-id":56887,"id":"Q56887"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$5C7E01DB-6395-48E0-B1A3-7FC0B7B04A87","rank":"normal"}],"P159":[{"mainsnak":{"snaktype":"value","property":"P159","hash":"d99783635b6158c76ea777c30c0255e487c157fe","datavalue":{"value":{"text":"Recurrent neural network-based model predictive control for continuous pharmaceutical manufacturing","language":"en"},"type":"monolingualtext"},"datatype":"monolingualtext"},"type":"statement","id":"Q1634707$6B43D071-F0C9-4B14-A12B-CD3B8944BCF3","rank":"normal"}],"P225":[{"mainsnak":{"snaktype":"value","property":"P225","hash":"a8cf762711482bc32d176174a6a4c77b021bebdd","datavalue":{"value":"1405.93171","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$E88CBFDC-A940-4B37-BB29-9084C23E70FB","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"f2a13d629b24437ed53b3e9daf0aa91a76bc3ed1","datavalue":{"value":{"entity-type":"item","numeric-id":1634703,"id":"Q1634703"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$CB29B039-0FDB-45B2-8798-3CDD32510789","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"23beed7ce120835ca6eebda0881e527e848c03c0","datavalue":{"value":{"entity-type":"item","numeric-id":1634704,"id":"Q1634704"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$1561493E-8C78-490C-A542-81A3B718EEAA","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"54f372d888619f43f0a1ce244a8ab6332ec2e2c9","datavalue":{"value":{"entity-type":"item","numeric-id":1634705,"id":"Q1634705"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$3F81A6B6-3DA1-4858-B40B-F70901B650E6","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"49ea43f64c5e07805f45cba7c6a5010200923675","datavalue":{"value":{"entity-type":"item","numeric-id":1634706,"id":"Q1634706"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$B2E1D894-3543-4E68-8C6B-19D3B434D89B","rank":"normal"}],"P200":[{"mainsnak":{"snaktype":"value","property":"P200","hash":"69c6b4591e97699b142121ab7ad8265f483cc8e3","datavalue":{"value":{"entity-type":"item","numeric-id":61563,"id":"Q61563"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$6FC10B3C-B903-46BC-9504-8C68AC9DB913","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"a0f227618f212e1aabdb733def27a9d54ea538c8","datavalue":{"value":{"time":"+2018-12-18T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q1634707$F822B6B8-B89B-4718-A789-9967B38F5631","rank":"normal"}],"P205":[{"mainsnak":{"snaktype":"value","property":"P205","hash":"5c551566cef4f3a66c934664f92e8219211bf11c","datavalue":{"value":"https://arxiv.org/abs/1807.09556","type":"string"},"datatype":"url"},"type":"statement","id":"Q1634707$63FD4254-0230-4B71-8611-17A07DD401AD","rank":"normal"}],"P1448":[{"mainsnak":{"snaktype":"value","property":"P1448","hash":"f6536a3fc44fbdf8eccfe3b454086d9628e52a7f","datavalue":{"value":"Summary: The pharmaceutical industry has witnessed exponential growth in transforming operations towards continuous manufacturing to increase profitability, reduce waste and extend product ranges. Model Predictive Control (MPC) can be applied to enable this vision by providing superior regulation of Critical Quality Attributes (CQAs). For MPC, obtaining a workable system model is of fundamental importance, especially if complex process dynamics and reaction kinetics are present. Whilst physics-based models are desirable, obtaining models that are effective and fit-for-purpose may not always be practical, and industries have often relied on data-driven approaches for system identification instead. In this work, we demonstrate the applicability of Recurrent Neural Networks (RNNs) in MPC applications in continuous pharmaceutical manufacturing. RNNs were shown to be especially well-suited for modeling dynamical systems due to their mathematical structure, and their use in system identification has enabled satisfactory closed-loop performance for MPC of a complex reaction in a single Continuous-Stirred Tank Reactor (CSTR) for pharmaceutical manufacturing.","type":"string"},"datatype":"string"},"type":"statement","id":"Q1634707$39755F83-92D3-46F2-A52B-9B739204AD39","rank":"normal"}],"P226":[{"mainsnak":{"snaktype":"value","property":"P226","hash":"c9727d9ee90ef6c0f1bdf0ba5bb711e9a6b7cd05","datavalue":{"value":"93C95","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$F666FD15-71C8-4371-90AC-BDCCB3776923","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"cfe779e91fe9c53ee133568259955801965765ae","datavalue":{"value":"68T05","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$E7D95CA3-AFA4-4D09-AFA3-3E4BC459295E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"f47b8551cfcd2e27e18ae083a8521741e193efcd","datavalue":{"value":"93B30","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$6E5D6E07-35AF-4BE8-B3CA-4396862B85C6","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"10e7ae4f3272e1b3be03ffc40fe137c122ddd99d","datavalue":{"value":"93B40","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$1485BBA6-783D-4855-85A2-F0D3AE7DE36C","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"998e2315eb586146fa99a11c3609a6857593a7bd","datavalue":{"value":"92B20","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$FAF874D0-24AA-4316-9143-9BD183E61042","rank":"normal"}],"P1451":[{"mainsnak":{"snaktype":"value","property":"P1451","hash":"db0bc43acd4885dc2ce23ec4ddaee3e391a3d4fb","datavalue":{"value":"6994845","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$624F506E-F019-4F35-AF2B-35C420CCB68D","rank":"normal"}],"P1450":[{"mainsnak":{"snaktype":"value","property":"P1450","hash":"2ebc1b9cff0f8bf8d397e59511a6735b3dd50eab","datavalue":{"value":"pharmaceuticals","type":"string"},"datatype":"string"},"type":"statement","id":"Q1634707$C566031D-DD26-4149-9B7B-567A86F62AA0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"6dccebccec4870728653efc2e32b307e82920dd1","datavalue":{"value":"critical quality attributes (CQAs)","type":"string"},"datatype":"string"},"type":"statement","id":"Q1634707$10B11374-794B-4625-9CBF-9B4CD9729ED8","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"1bb3d834d03fe1fa31207629b1eb5842c280b221","datavalue":{"value":"recurrent neural networks","type":"string"},"datatype":"string"},"type":"statement","id":"Q1634707$CEFF7974-996F-43C9-B423-68DFF2DECD36","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"820432e3909491efe715a4a84ca7b9f64be26bef","datavalue":{"value":"model predictive control (MPC)","type":"string"},"datatype":"string"},"type":"statement","id":"Q1634707$6D5BB523-141F-499A-A1D6-78D54C3BB39C","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"9849827e83b757ceaea7e4ead19cebc299ae297b","datavalue":{"value":"system identification","type":"string"},"datatype":"string"},"type":"statement","id":"Q1634707$F91C64AA-5B72-4994-BCCE-33BCCC2E8616","rank":"normal"}],"P1463":[{"mainsnak":{"snaktype":"value","property":"P1463","hash":"30bf75efb36ce548a631ba3177096a709329cc05","datavalue":{"value":{"entity-type":"item","numeric-id":34000,"id":"Q34000"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$EAFA64CD-4BA9-4A4D-B3A7-7B5EC6F9FD55","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"57f7fea50d2ce1b39b695c4a1313582eed405e38","datavalue":{"value":{"entity-type":"item","numeric-id":5976449,"id":"Q5976449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$BD374898-AD11-48D4-BBF3-A2E757983199","rank":"normal"}],"P388":[{"mainsnak":{"snaktype":"value","property":"P388","hash":"affc56d0766094227e9c9dd242b2d6cfcb834ea0","datavalue":{"value":"W2883194111","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$ADBD1CDC-86B4-4E40-8602-30014FB551DE","rank":"normal"}],"P223":[{"mainsnak":{"snaktype":"value","property":"P223","hash":"eb222fba28d402409e945d825ad0cf026a9a2cb2","datavalue":{"value":{"entity-type":"item","numeric-id":859367,"id":"Q859367"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$8AC281BE-B77E-449E-ABC1-720CAB6B89C3","rank":"normal"}],"P12":[{"mainsnak":{"snaktype":"value","property":"P12","hash":"ab156c409a210d40ce1ad29c77f9b64f47918748","datavalue":{"value":"Q128954910","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$4B526BF4-8DCF-4B02-8A7A-B2B4030EE3EC","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"d31363b4ba895d51531e5aa07edfceca83d22f88","datavalue":{"value":"10.3390/MATH6110242","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1634707$0DE10147-9ABE-4ED0-8D40-4D1886DA96A0","rank":"normal"}],"P1643":[{"mainsnak":{"snaktype":"value","property":"P1643","hash":"0d90403ea3d97040e7cc4640d5222759ae50d5ee","datavalue":{"value":{"entity-type":"item","numeric-id":1606525,"id":"Q1606525"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"1f3c1086c9b38ec4dcfa8c2a492c052856c6d99d","datavalue":{"value":{"amount":"+0.6749439835548401","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1634707$71C32B9F-E6D1-498A-A2F9-68482E5FCC50","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"db11d12293578aa65b8f9aaef514cbbb58c07dc2","datavalue":{"value":{"entity-type":"item","numeric-id":2673618,"id":"Q2673618"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"efb394c5963aaef9600f0ca826a833f0172c268f","datavalue":{"value":{"amount":"+0.6643140316009521","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1634707$75722D3B-F381-4638-9BDD-1D46E68D9897","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"1792be2b0f0fe98f682ab657fe30327c1f875de6","datavalue":{"value":{"entity-type":"item","numeric-id":2814047,"id":"Q2814047"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"597d682ad3e311873e2b1c3b98575cab6b107982","datavalue":{"value":{"amount":"+0.6620894074440002","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1634707$F1BED0EC-4AEB-4596-8443-F2AA2018F3DE","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"fdca46882c277295ce5de181fe1cbec04d6c482f","datavalue":{"value":{"entity-type":"item","numeric-id":1852036,"id":"Q1852036"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"db18e8a8016617163f45a44fba68227a4310e021","datavalue":{"value":{"amount":"+0.6615316271781921","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1634707$2AD7A53F-C8A8-4415-B0C0-39DC82F0FC8D","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"86ad2723f2bf5cecca32c3b9d3fc4b611333922b","datavalue":{"value":{"entity-type":"item","numeric-id":5198763,"id":"Q5198763"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"ffc0fe10decf7c1f5fbd8e7015d4dfe8168e3b3f","datavalue":{"value":{"amount":"+0.6610110998153687","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1634707$2B68DD4D-4415-47CB-BFDA-151068018DB9","rank":"normal"}],"P163":[{"mainsnak":{"snaktype":"value","property":"P163","hash":"45fcd4163b5f33e6e8c784f5522d7246c0a1a61e","datavalue":{"value":{"entity-type":"item","numeric-id":57056,"id":"Q57056"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1634707$AA303FA7-0916-438F-8993-43594CB17ED3","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"Publication:1634707","badges":[]}}}}}