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The author studies the Castelnuovo-Mumford regularity of a finitely generated graded $S$-module $M$ and equivalently of a coherent sheaf $\\mathcal{F}$ of $\\mathbb{P}^n_k$ under the additional assumption that $M$ is equi-dimensional and locally Cohen-Macaulay. Let $V \\subset \\mathbb{P}^n_k$ be a $d$-dimensional projective scheme such that $(\\star) \\; \\mathfrak{m}^v H^i_{\\star}(\\mathcal{I}_V) = 0$ for $i = 1,\\ldots,\\dim V$. Motivated by the work of \\textit{U. Nagel} and the reviewer (see [Nagoya Math. J. 152, 153--174 (1998; Zbl 0945.13008)]) and the author and \\textit{W. Vogel} [J. Algebra 185, No. 3, 626--642 (1996; Zbl 0912.13007)] the author studies bounds of the following type \\[ \\text{reg} V \\leq \\lceil (\\deg V -1)/\\text{codim}V\\rceil + C(d,v). \\] Note that $C(d,v) = 1$ for the case that $V$ is arithmetically Buchsbaum. As a main result it is shown that $C(d,v) = (v-1) \\dim V +1$, whenever $(\\star)$ is satisfied for any proper intersection $V_j = V \\cap H_1 \\cap \\ldots \\cap H_j$ of generic hyperplanes. As a technical tool the author studies Koszul homology and the highest non-vanishing degree of 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