{"entities":{"Q1737299":{"pageid":1748040,"ns":120,"title":"Item:Q1737299","lastrevid":57352188,"modified":"2026-03-30T14:59:25Z","type":"item","id":"Q1737299","labels":{"en":{"language":"en","value":"Fast and accurate genome-wide association test of multiple quantitative traits"}},"descriptions":{"en":{"language":"en","value":"scientific article; zbMATH DE number 7042930"}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"fd5912e4dab4b881a8eb0eb27e7893fef55176ad","datavalue":{"value":{"entity-type":"item","numeric-id":56887,"id":"Q56887"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$A72BCBA7-158E-4BEC-ADBC-A2A5D9CF96E5","rank":"normal"}],"P159":[{"mainsnak":{"snaktype":"value","property":"P159","hash":"4aef206ce15c352ea750987f1b90d9e69901071e","datavalue":{"value":{"text":"Fast and accurate genome-wide association test of multiple quantitative traits","language":"en"},"type":"monolingualtext"},"datatype":"monolingualtext"},"type":"statement","id":"Q1737299$7590F30C-7E5C-423B-8C71-262ACA00C8E9","rank":"normal"}],"P225":[{"mainsnak":{"snaktype":"value","property":"P225","hash":"689bcd7ace81c2965e6a746407cacde3a6db5498","datavalue":{"value":"1411.92203","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1737299$3BE98202-796E-4D2E-928E-366E9592CB63","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"328a703b1914d380c863ea6f0843b2f605919d7e","datavalue":{"value":"10.1155/2018/2564531","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1737299$0305A348-A32F-4F4C-9281-FFB33C4382C8","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"2b8222c3f764285a300a01d0e1bb0d307cee9549","datavalue":{"value":{"entity-type":"item","numeric-id":783328,"id":"Q783328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$72D52FA4-9271-441C-86CA-AB0DC67507C3","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"d2bbf15a8840824b490a3a7dc0e8719009103115","datavalue":{"value":{"entity-type":"item","numeric-id":1737298,"id":"Q1737298"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$085B305D-713E-4C58-808D-4B50618C4F70","rank":"normal"}],"P200":[{"mainsnak":{"snaktype":"value","property":"P200","hash":"ae2a137607979ebaa11579b7aa87d8ebbaf2710b","datavalue":{"value":{"entity-type":"item","numeric-id":278087,"id":"Q278087"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$5B419BE8-191C-43C1-9063-4336A5DD9CCE","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"d06bbe883443d922d03e742956c1e568349f86c8","datavalue":{"value":{"time":"+2019-03-27T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q1737299$536E868D-930F-41DE-8EAD-C584AC3C757E","rank":"normal"}],"P1448":[{"mainsnak":{"snaktype":"value","property":"P1448","hash":"2545697f879cfe8e940a9cc997294a62d614f709","datavalue":{"value":"Summary: Multiple correlated traits are often collected in genetic studies. By jointly analyzing multiple traits, we can increase power by aggregating multiple weak effects and reveal additional insights into the genetic architecture of complex human diseases. In this article, we propose a multivariate linear regression-based method to test the joint association of multiple quantitative traits. It is flexible to accommodate any covariates, has very accurate control of type I errors, and offers very competitive performance. We also discuss fast and accurate significance \\(p\\) value computation especially for genome-wide association studies with small-to-medium sample sizes. We demonstrate through extensive numerical studies that the proposed method has competitive performance. Its usefulness is further illustrated with application to genome-wide association analysis of diabetes-related traits in the atherosclerosis risk in communities (ARIC) study. We found some very interesting associations with diabetes traits which have not been reported before. We implemented the proposed methods in a publicly available R package.","type":"string"},"datatype":"string"},"type":"statement","id":"Q1737299$8F38302B-58B1-46A9-B0D3-58A5334C72FD","rank":"normal"}],"P226":[{"mainsnak":{"snaktype":"value","property":"P226","hash":"8acfb5681686a479769f1498162f25169e468cda","datavalue":{"value":"92D10","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1737299$A0EC4F1B-F5C2-469A-B442-02D402E69B44","rank":"normal"}],"P1451":[{"mainsnak":{"snaktype":"value","property":"P1451","hash":"5cfaa4fee6748d17605b40016a7436e59725d7fb","datavalue":{"value":"7042930","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1737299$EE8462BD-DE7B-487D-AB30-99FEC1A03A09","rank":"normal"}],"P1450":[{"mainsnak":{"snaktype":"value","property":"P1450","hash":"b14980e78cd976e9c3e11197a9ad57a498dd1af1","datavalue":{"value":"diabetes-related traits","type":"string"},"datatype":"string"},"type":"statement","id":"Q1737299$5D3FE262-0CCC-4C08-B522-A7854F12074C","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"163ca2ca6cea1e1256cb2a83c90a69fe69260bec","datavalue":{"value":"genome-wide association test","type":"string"},"datatype":"string"},"type":"statement","id":"Q1737299$E7E14881-612B-4EF7-BF35-56E3FA65AD15","rank":"normal"}],"P1463":[{"mainsnak":{"snaktype":"value","property":"P1463","hash":"6d09a07fbe4772911eced78336455f54d50fcc6a","datavalue":{"value":{"entity-type":"item","numeric-id":39767,"id":"Q39767"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$7DF0F3C5-3025-4A31-A1FD-6B544D5E49E0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1463","hash":"b2f45492d0a9ee38c7f6f7ea29a7881599069d9b","datavalue":{"value":{"entity-type":"item","numeric-id":13519,"id":"Q13519"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$939D2D0D-57C0-4389-B8EC-DFD9C2F85B55","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1463","hash":"4fc1a21339bf57fcd3fb28f3310bd7c50400e6e1","datavalue":{"value":{"entity-type":"item","numeric-id":16752,"id":"Q16752"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$CB4F4FD7-EC79-44DB-A360-CC8E27404B1E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1463","hash":"60a92a3682b1c7ec082153e85afa7b4f02ed0d10","datavalue":{"value":{"entity-type":"item","numeric-id":29134,"id":"Q29134"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$7C2EA3F0-8474-4138-8439-B9FC9C108E91","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1463","hash":"9316a19f3ad458004812103e3a42e934da590e1b","datavalue":{"value":{"entity-type":"item","numeric-id":31866,"id":"Q31866"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$1218FB0A-437D-4DDF-B35E-B899DDDC15CE","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"57f7fea50d2ce1b39b695c4a1313582eed405e38","datavalue":{"value":{"entity-type":"item","numeric-id":5976449,"id":"Q5976449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$027F3437-D185-4D1A-A6CF-FD0475B46E29","rank":"normal"}],"P205":[{"mainsnak":{"snaktype":"value","property":"P205","hash":"5aed6e507cc1a69fb80336473d21c38fdddf728b","datavalue":{"value":"https://doi.org/10.1155/2018/2564531","type":"string"},"datatype":"url"},"type":"statement","id":"Q1737299$84C0E1E4-C49D-4CBB-8634-E54E37F85292","rank":"normal"}],"P388":[{"mainsnak":{"snaktype":"value","property":"P388","hash":"6d4793a6dcc900745329eecd9834e3283ce11d7d","datavalue":{"value":"W2792678157","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1737299$FC3B5FAC-B98D-4FFE-B51A-E936FBA9E91A","rank":"normal"}],"P12":[{"mainsnak":{"snaktype":"value","property":"P12","hash":"4cdf0554c9532dddd4caaa1daf307c2087cbacbd","datavalue":{"value":"Q55073682","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1737299$E2027305-804B-4C2C-9256-CFB5EBFF967B","rank":"normal"}],"P223":[{"mainsnak":{"snaktype":"value","property":"P223","hash":"5ff2abe227f8b0fb4aad58f73dc90c1310113b9f","datavalue":{"value":{"entity-type":"item","numeric-id":81826,"id":"Q81826"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$8CCF512A-3A66-4036-A7B7-45BB092F651A","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"5ab571d35a7111d38f47c8ea95afc0b10ed2c3ed","datavalue":{"value":{"entity-type":"item","numeric-id":4420195,"id":"Q4420195"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$837121F1-FBF7-4828-A207-7AE7602F0F3E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"d5321086b7af477dbd8c787e948186b1e3d67f02","datavalue":{"value":{"entity-type":"item","numeric-id":5671469,"id":"Q5671469"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$F8519B31-9178-4730-95C0-20113D27FD34","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"e628e9a3446c47dc621db0f234ff8470d1fed02e","datavalue":{"value":{"entity-type":"item","numeric-id":5538617,"id":"Q5538617"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$37F70049-B801-40AC-841F-D9AA8D9F13AB","rank":"normal"}],"P1635":[{"mainsnak":{"snaktype":"value","property":"P1635","hash":"3eb445fbc48ca347b6129b9902b9b2a5b6054c46","datavalue":{"value":"journals/cmmm/WuP18","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q1737299$97458A37-930F-45AA-842B-0CB591BA5291","rank":"normal"}],"P1643":[{"mainsnak":{"snaktype":"value","property":"P1643","hash":"1ac79ebdc38f7492beed3e539e896be4880baeeb","datavalue":{"value":{"entity-type":"item","numeric-id":3119821,"id":"Q3119821"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"33e546d24a9037689ad2bbb18e4ac801dc3232d3","datavalue":{"value":{"amount":"+0.8230000138282776","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1737299$55A2FB45-D137-498C-9F46-0BDBA17DE564","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"d6ea07c66c5e05d5b5e52abb0b498fcd0a4267f5","datavalue":{"value":{"entity-type":"item","numeric-id":5107574,"id":"Q5107574"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"3e4a990fb0b9d0df8a58c7601c907d6ae57c1590","datavalue":{"value":{"amount":"+0.7751220464706421","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1737299$609AEAD6-C2D2-466F-83B6-D6117A1A83E5","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"d84d4c424a8dec58fbd36f5944ece24561116024","datavalue":{"value":{"entity-type":"item","numeric-id":2344239,"id":"Q2344239"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"3b3662d10279e6a99992740e4f26665ce6385a5e","datavalue":{"value":{"amount":"+0.7555661797523499","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1737299$785E688F-3ADD-4B30-BB65-373DB8EDE4F9","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"e1b2a9be35d37a1a95424789aefa968e607e1a65","datavalue":{"value":{"entity-type":"item","numeric-id":5121018,"id":"Q5121018"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"5b03eddf56e5f03aa2883012ff4fdc3368b828df","datavalue":{"value":{"amount":"+0.7527734041213989","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1737299$72D6FE63-C545-47EB-BA65-540FB9121647","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"bcad8733abbd637c05873da0ba8a37498c397834","datavalue":{"value":{"entity-type":"item","numeric-id":2846449,"id":"Q2846449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"dbc258343cf715480a3d0610416716cf67c775e1","datavalue":{"value":{"amount":"+0.748031497001648","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q1737299$2C362A9A-23C0-4B5E-846D-2771FA781400","rank":"normal"}],"P163":[{"mainsnak":{"snaktype":"value","property":"P163","hash":"45fcd4163b5f33e6e8c784f5522d7246c0a1a61e","datavalue":{"value":{"entity-type":"item","numeric-id":57056,"id":"Q57056"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q1737299$04554DD5-F1AF-4807-80D1-66D845F54EFC","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"Publication:1737299","badges":[],"url":"https://portal.mardi4nfdi.de/wiki/Publication:1737299"}}}}}