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In the more general case of Carnot-Carath\u00e9odory spaces, isoperimetric inequalities are discussed by Gromov and the others. But in all previous results there are no sharp constants obtained. In this paper the authors prove a sharp isometric inequality in the Grushin plane, precisely they give the following  Theorem 1: Let \\(\\alpha\\geq 0\\). For any measurable set \\(E\\subset \\mathbb R^2\\) with finite measure \\(|E|\\), define its \\(\\alpha\\)-perimeter as  \\[ P\\alpha(E)= \\sup\\biggl\\{\\int_E(\\partial_x\\varphi_1+ |x|^{\\alpha}\\partial_y\\varphi_2)\\,dx\\,dy: \\varphi_1,\\varphi_2\\in C^1_0 (\\mathbb R^2),\\;\\sup_{\\mathbb R^2}(\\varphi_1^2+ \\varphi_2^2)^{1/2}\\leq 1\\biggr\\}. \\]  Then we have  \\[ |E|\\leq\\frac{\\alpha+ 1} {\\alpha+2}\\Biggl(2\\int_0^{\\pi}\\sin^\\alpha t\\,dt\\Biggr)^{-\\frac{1} {\\alpha+1}}P_{\\alpha}(E)^{\\frac{\\alpha+2}{\\alpha+1}}. \\]  Equality holds for the isoperimetric set  \\[ E_{\\alpha}= \\Biggr\\{(x,y)\\in \\mathbb R^2: |y| < \\int_{\\arcsin|x|}^{\\pi/2}\\sin^{\\alpha+ 1}t\\,dt,|x|< 1\\Biggr\\}. \\]  If \\(\\alpha> 0\\), isoperimetric sets are unique up to vertical translations and dilations of the form \\((x,y)\\to \\delta_{\\lambda}(x, y)= (\\lambda x, \\lambda^{\\alpha+ 1}y)\\), \\(\\lambda> 0\\).  From Theorem 1 we can get a Gagliardo-Nirenberg inequality for the Grushin sub-elliptic gradient, i.e.  \\[ \\biggl(\\int_{\\mathbb R^2}|f|^{\\frac{d}{d- 1}}dx\\,dy\\biggr)^{\\frac{d- 1}{d}} \\leq c(\\alpha)^{\\frac{d-1}{d}} \\int_{\\mathbb R^2}(|\\partial_x f|^2+ |x|^{2\\alpha} |\\partial_yf|^2)^{1/2}\\,dx\\,dy \\]  for all functions \\(f\\in C^\\infty_0(\\mathbb R^2)\\), where \\(d= \\alpha+ 2\\) and \\(c(\\alpha)= \\frac{\\alpha+1} {\\alpha+ 2}(2\\int_ 0^{\\pi}\\sin^{\\alpha}t\\,dt)^{-\\frac{1} {\\alpha+ 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