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The Casson fluid model is applied to characterize the non-Newtonian fluid behavior. Physical mechanisms responsible for Brownian motion and thermophoresis with chemical reaction are accounted for in the model. The governing nonlinear boundary layer equations through appropriate transformations are reduced into a set of nonlinear ordinary differential equations, which are solved numerically using a shooting method with fourth-order Runge-Kutta integration scheme. Comparisons of the numerical method with the existing results in the literature are made and an excellent agreement is obtained. The heat transfer rate is enhanced with generative chemical reaction and concentration slip parameter, whereas the reverse trend is observed with destructive chemical reaction and thermal slip parameter. It is also noticed that the mass transfer rate is boosted with destructive chemical reaction and thermal slip parameter. 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