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Mukai} [Encycl. Math. Sci. 132, 123--129 (2004; Zbl 1108.13300)] and \\textit{A.-M. Castravet} and \\textit{J. Tevelev} [Compos. Math. 142, No. 6, 1479--1498 (2006; Zbl 1117.14048)] proved that the blow-up of $(\\mathbb{P}^n)^r$ at $s$ general points is a Mori dream space if and only if $1/(r+1) + 1/(s-n-1)+1/(n+1)>1$. \\textit{C. Araujo} and \\textit{A. Massarenti} [Proc. Lond. Math. Soc. (3) 113, No. 4, 445--473 (2016; Zbl 1364.14033)] and \\textit{J. Lesieutre} and \\textit{J. Park} [Proc. Am. Math. Soc. 145, No. 10, 4201--4209 (2017; Zbl 1370.14035)] showed that these blown-up spaces are log Fano. It is a natural problem to determine which blow-ups of products of projective spaces admit log Fano structures. In the paper under review, the author considers the successive blow-ups $\\widetilde{X}$ of $Y:=\\mathbb{P}^{n-k} \\times \\mathbb{P}^k$ with $n \\geq 3$ and $2 \\leq k \\leq n-1$ along $C$ and then along the strict transform of $S$, where $C$ is a smooth hypersurface of degree $d$ in a fiber of the projection $Y \\to \\mathbb{P}^{n-k}$, and $S$ is a fiber of the other projection $Y \\to \\mathbb{P}^k$. The main result (Theorem 1) is the following: (1) $\\widetilde{X}$ is always log Fano.  (2) $\\widetilde{X}$ is weak Fano if and only if  \\[ (n,k,d)=(3,2,1), (3,2,2), (3,2,3), (5,3,2), (2k-1, k, 1), (2k,k,1), (2k+1, k,1)\\text{  with  }k \\geq 2. \\] (3) $\\widetilde{X}$ is Fano if and only if $(n,k,d)=(2k, k, 1)$ with $k \\geq 2$.  The main ingredient of the proof is the explicit computation of the nef cone $\\operatorname{Nef}(\\widetilde{X})$ (Proposition 2). 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