{"entities":{"Q2265965":{"pageid":2276708,"ns":120,"title":"Item:Q2265965","lastrevid":71717856,"modified":"2026-04-14T00:05:19Z","type":"item","id":"Q2265965","labels":{"en":{"language":"en","value":"An optimal control problem in the study of liver kinetics"}},"descriptions":{"en":{"language":"en","value":"scientific article; zbMATH DE number 3893001"}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"fd5912e4dab4b881a8eb0eb27e7893fef55176ad","datavalue":{"value":{"entity-type":"item","numeric-id":56887,"id":"Q56887"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2265965$33EC0AC0-908F-47AF-A484-762DF11CC3A4","rank":"normal"}],"P159":[{"mainsnak":{"snaktype":"value","property":"P159","hash":"51a418e317b18c0fe2db7d9e294a2dd36f64ff72","datavalue":{"value":{"text":"An optimal control problem in the study of liver kinetics","language":"en"},"type":"monolingualtext"},"datatype":"monolingualtext"},"type":"statement","id":"Q2265965$341B88AB-83F2-41FC-AC3A-F0A50AEC73D6","rank":"normal"}],"P225":[{"mainsnak":{"snaktype":"value","property":"P225","hash":"100619e55d99c469b833111ddd425664406f5f79","datavalue":{"value":"0559.92015","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2265965$7F18F22C-4CA7-4238-88D0-4C4649291E55","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"af410c108577ef80c98c3bb3786e38fc9ae6c85b","datavalue":{"value":"10.1007/BF00940674","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2265965$6EE75A81-DBAD-43E8-9B3D-8EAF6DCE3440","rank":"normal"}],"P200":[{"mainsnak":{"snaktype":"value","property":"P200","hash":"a3c8bf4d8569c126380a9fc42f55609089e776fb","datavalue":{"value":{"entity-type":"item","numeric-id":82026,"id":"Q82026"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2265965$E679737E-8884-4327-8B38-FC37882BD981","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"63df7153432d81fa42019fcabb076c89649b0b5b","datavalue":{"value":{"time":"+1986-00-00T00:00:00Z","timezone":0,"before":0,"after":0,"precision":9,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q2265965$C278D12A-3CA2-41CF-A49A-38EBF5AEAAAD","rank":"normal"}],"P1448":[{"mainsnak":{"snaktype":"value","property":"P1448","hash":"9862ea2a2e4e9b20b7468de3ab7e497ec585fb2b","datavalue":{"value":"The enzyme activities in the liver are described by a system of ordinary differential equations. A certain substance in the blood is transformed twice by different kinds of enzymes. The mathematical problem is to determine the distribution of enzymes along the blood flow so that the outflow concentration of the once-transformed form of the substance is as small as possible. This problem has been considered before and solved for particular types of enzyme kinetics.    In this paper, we solve the problem for more general types of kinetics (including substrate-inhibition kinetics). The methods used are also different in that the problem is considered as a problem of optimal control and Pontryagin's maximum principle is applied to derive necessary conditions.","type":"string"},"datatype":"string"},"type":"statement","id":"Q2265965$583B82A9-0CB2-49D1-B0E5-756BA41D26F7","rank":"normal"}],"P226":[{"mainsnak":{"snaktype":"value","property":"P226","hash":"408a79c1bfecc6ff58b5150b55e32f4d3c10746b","datavalue":{"value":"92Cxx","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2265965$8A2916B0-3C1D-42DF-B972-7A72119324D7","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"18d3ff98a6b36ff583aa8db8acc5f9669058d6c6","datavalue":{"value":"49K15","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2265965$7EA2CE6F-2C4A-4FA2-9410-6E08770CF133","rank":"normal"}],"P1451":[{"mainsnak":{"snaktype":"value","property":"P1451","hash":"009bfe4cb5cdaacaac0d30283e31c7257bfc7a89","datavalue":{"value":"3893001","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2265965$29D47DF0-1B3D-470F-9A84-9E1A8B36B9EE","rank":"normal"}],"P1450":[{"mainsnak":{"snaktype":"value","property":"P1450","hash":"78e4334ba46797ff445e6a7f601432283d877b0f","datavalue":{"value":"liver kinetics","type":"string"},"datatype":"string"},"type":"statement","id":"Q2265965$43982302-6145-4568-A1AC-27CE04143817","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"1a08df4a8cbcb4c78951818593b45dc255068ae1","datavalue":{"value":"distribution of enzymes along the blood flow","type":"string"},"datatype":"string"},"type":"statement","id":"Q2265965$FC03034E-7F1B-41AD-9470-47961C7B0998","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"d9a5f5d357992b8b95ebe22b675901431169ccdb","datavalue":{"value":"enzyme kinetics","type":"string"},"datatype":"string"},"type":"statement","id":"Q2265965$0BF7C3E3-A2AA-49A2-9749-68C43F85EF43","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"5fe1fa7d90f05a2276a1a9df2fc591c042358868","datavalue":{"value":"substrate-inhibition kinetics","type":"string"},"datatype":"string"},"type":"statement","id":"Q2265965$5D5498B8-11FA-4839-9EE9-59ED60EC03CD","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"24b57089134e6c38aad29924033d0c30e7e87ac2","datavalue":{"value":"Pontryagin's maximum principle","type":"string"},"datatype":"string"},"type":"statement","id":"Q2265965$84C22A03-D698-4472-BFAF-31EAD4F14C5F","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"51c51f29a096836c61c3f225268b55d86939623a","datavalue":{"value":"necessary conditions","type":"string"},"datatype":"string"},"type":"statement","id":"Q2265965$E871E4C8-E44B-46EB-A161-94571CCB06E4","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"bfd887c9a3f5c545a2fa8469064de2201003c0eb","datavalue":{"value":{"entity-type":"item","numeric-id":581832,"id":"Q581832"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2265965$A49F46FC-19A3-4D1B-8FDF-3CF587DCEBCD","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"57f7fea50d2ce1b39b695c4a1313582eed405e38","datavalue":{"value":{"entity-type":"item","numeric-id":5976449,"id":"Q5976449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2265965$F7BBB5C8-4621-4348-96FB-F451281D72D5","rank":"normal"}],"P223":[{"mainsnak":{"snaktype":"value","property":"P223","hash":"deec9c47b42b26d012a2b697167a952b00c9c821","datavalue":{"value":{"entity-type":"item","numeric-id":3320169,"id":"Q3320169"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2265965$656D7B2F-1DF9-4D8B-9FDE-C536D5926AE6","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"69c6053474c8a47b1b2379bcf1ce5d891da3ba61","datavalue":{"value":{"entity-type":"item","numeric-id":5848416,"id":"Q5848416"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2265965$5CD97C18-C89C-4520-BB17-199EDB6EBA44","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"d8f76cafc2b216fa3461f88e60bfc9fe57b6c5b0","datavalue":{"value":{"entity-type":"item","numeric-id":1213163,"id":"Q1213163"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2265965$FBD36F99-524C-4DD6-99CE-8DCEB5F4C0CD","rank":"normal"}],"P1643":[{"mainsnak":{"snaktype":"value","property":"P1643","hash":"5cbb80f962ad313777fa1f760b4473f886370de2","datavalue":{"value":{"entity-type":"item","numeric-id":3315322,"id":"Q3315322"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"ce27e3cefebfe145473c7811ad9766981544b9f1","datavalue":{"value":{"amount":"+0.9811648726463318","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2265965$BD29016F-CA86-4A43-8D5A-96F9B4C1AE09","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"ecbbbe359a218207a8519576394d462a7f1719d8","datavalue":{"value":{"entity-type":"item","numeric-id":3720352,"id":"Q3720352"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"19838a0d33465e68cf39bad38cc457a9d535b2d7","datavalue":{"value":{"amount":"+0.8776673674583435","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2265965$91A2F7E6-0178-4A06-B0CE-BD424D89A496","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"b93f473733d75d615627f8678a338f213b9c0464","datavalue":{"value":{"entity-type":"item","numeric-id":3320169,"id":"Q3320169"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"b7c4dca18db4dc4559379f8d798b9e2463364d65","datavalue":{"value":{"amount":"+0.8259819746017456","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2265965$2E925DA6-C54E-4D89-A521-512ABC09732A","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"b45edb49ffa5a609020a92aabeaf8039f820b148","datavalue":{"value":{"entity-type":"item","numeric-id":1321106,"id":"Q1321106"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"8f4cf334b7178aaf1e916c105ac782c4266de2e5","datavalue":{"value":{"amount":"+0.8082707524299622","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2265965$4FB2CFF8-0B2E-4BDC-B1CE-2E7C5D414BB4","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"b2f0beefa446d383a24ff31a6c1248c60cae876a","datavalue":{"value":{"entity-type":"item","numeric-id":3988951,"id":"Q3988951"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"9623d7e9b30e1b3f2d9c9d2445db2a3da5973676","datavalue":{"value":{"amount":"+0.7837736010551453","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2265965$C60B9C39-CC04-4673-A59A-71D54E2FD6E2","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"An optimal control problem in the study of liver kinetics","badges":[]}}}}}