{"entities":{"Q2317230":{"pageid":2327973,"ns":120,"title":"Item:Q2317230","lastrevid":43871841,"modified":"2025-11-15T16:34:54Z","type":"item","id":"Q2317230","labels":{"en":{"language":"en","value":"On applications of the Hamilton-Jacobi equations and optimal control theory to problems of chemotherapy of malignant tumors"}},"descriptions":{"en":{"language":"en","value":"scientific article; zbMATH DE number 7091506"}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"fd5912e4dab4b881a8eb0eb27e7893fef55176ad","datavalue":{"value":{"entity-type":"item","numeric-id":56887,"id":"Q56887"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$3E79FEB7-62D9-4A67-8EF8-6B73620A4665","rank":"normal"}],"P159":[{"mainsnak":{"snaktype":"value","property":"P159","hash":"278d88b1e1c4bdec7be55ec618a318ea26f0c603","datavalue":{"value":{"text":"On applications of the Hamilton-Jacobi equations and optimal control theory to problems of chemotherapy of malignant tumors","language":"en"},"type":"monolingualtext"},"datatype":"monolingualtext"},"type":"statement","id":"Q2317230$A5D322BF-7ED1-4796-A063-33432323F14A","rank":"normal"}],"P225":[{"mainsnak":{"snaktype":"value","property":"P225","hash":"192f28874d1b4c5045f25ad9dd9a31bc65044b30","datavalue":{"value":"1422.49044","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$924CB4B4-95BE-4C0D-AF51-948EE8EBD429","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"0124514c0437fc001e139af67102871905f7dd8c","datavalue":{"value":"10.1134/S008154381901019X","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$1F067118-63C5-44C9-ADDD-24311656FA73","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"58f41d8bcdab325610b727db286a827e08b561a9","datavalue":{"value":{"entity-type":"item","numeric-id":265859,"id":"Q265859"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$B204E788-4F05-4DFD-8A2D-DA380F3DB938","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"ea460c0a07e25509470aa8bcac95162313e76e5a","datavalue":{"value":{"entity-type":"item","numeric-id":2317229,"id":"Q2317229"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$C872725B-B058-46AD-B352-85E169C52BD2","rank":"normal"}],"P200":[{"mainsnak":{"snaktype":"value","property":"P200","hash":"52ab463cca8ead400441fcc2b4fac1f6fbb55915","datavalue":{"value":{"entity-type":"item","numeric-id":251486,"id":"Q251486"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$7B6FABA9-EC0B-47C5-8047-78461DCCFD09","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"9d65be9b46b8dac95d31b784aa70a87e27ab8512","datavalue":{"value":{"time":"+2019-08-09T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q2317230$B0C50E3C-30B0-4457-833E-83DCD7019334","rank":"normal"}],"P1448":[{"mainsnak":{"snaktype":"value","property":"P1448","hash":"d6eb79a2111747f5bf18c85ea17a3fd893da1207","datavalue":{"value":"The work investigates a problem in an interesting domain of applications of control theory, in medicine, and precisely in malignant tumors therapy.  Following mathematical model for the chemotherapy of a malignant tumor is considered:  \\(\\frac{dm}{dt}=g(m)-\\gamma mg(h)\\), \\(\\frac{dh}{dt}=-\\alpha h+u(t)\\) , \\(m(t_o)=m_o\\), \\(h(t_o)=h_o\\), \\(\\gamma>0\\), \\(\\alpha>0\\), where \\(m\\) denotes the number of malignant cells, \\(h\\) the number of drugs that can kill tumor cells, \\(f(h)\\) is the therapy function describing the effect of a drug on tumor cells, \\(u(t)\\) -- the control function -- denotes the number of drugs injected into a tumor at time \\(t\\) and \\(g(m)\\) is a function of malignant cells growing according to a logistic low. The therapy function is a piecewise monotone continuous differentiable function. The goal of the study is to find an admissible control \\(u(t)\\) able to minimize at the end \\(T\\) of the process a cost function modeling the number of malignant cells, \\(\\sigma(m(T))=m^{\\beta}\\) \\((T;t_o;m_o;h_o;u(.))\\) This is a classical optimal control problem. The value function is introduced and calculated. Under some additional assumptions the optimal control for the stated problem is obtained.","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$CF37A222-BFEB-4196-B100-37A524399A81","rank":"normal"}],"P1447":[{"mainsnak":{"snaktype":"value","property":"P1447","hash":"11ff673257c55e5aa5c7c004d46b0d51fe07c6ab","datavalue":{"value":{"entity-type":"item","numeric-id":589968,"id":"Q589968"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$3175B52E-DECF-4A2A-825D-2E2DDC702A90","rank":"normal"}],"P226":[{"mainsnak":{"snaktype":"value","property":"P226","hash":"4de2df0b69afab23c60d6c04e16795a85069b4f1","datavalue":{"value":"49S05","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$4CAE68DF-5591-4395-9F14-CF939ADFD47B","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"46f6f97ad6bf74faa2be6629aac320ad56ec94a7","datavalue":{"value":"49J15","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$ABDD5C44-2622-4C33-8104-E85539AFD5B8","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"e27beffea4779e8a96e7c5961e8cc7879483d808","datavalue":{"value":"92C50","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$586975D0-C11D-401D-952C-62D7C8AC2F70","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"deb6ff57da5c76ad659aeb94b3df9cd98b4ae6e1","datavalue":{"value":"92C37","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$0F7C158A-2064-4C05-9555-0CE51AC8D17B","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"f93185088b25342e1fca63161ee1816b55989835","datavalue":{"value":"49N35","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$8AA54BB8-ED69-4286-9B1E-EED50D359568","rank":"normal"}],"P1451":[{"mainsnak":{"snaktype":"value","property":"P1451","hash":"be130bc5a42be1b9633a80473249e01d0aff5244","datavalue":{"value":"7091506","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$638C6BA3-8B52-4050-9728-631E9F7CB85E","rank":"normal"}],"P1450":[{"mainsnak":{"snaktype":"value","property":"P1450","hash":"f47fee90c5592664decba5aa2e51ae852ecd7730","datavalue":{"value":"optimal control","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$4F4FDD5E-BDD2-4907-85CD-8C2B26E28EC7","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"989c743fb94f6452a98afaeb2aa743eafed75420","datavalue":{"value":"chemotherapy","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$4147764D-B312-44DC-B08E-1E008F175766","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"f9df40203feed6886e69cc5c2594c17699692b83","datavalue":{"value":"malignant tumors","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$E2241E00-52C0-475B-A94E-1C26304D4525","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"60a9ddaad371c5de99845b002d7261e34b63d90c","datavalue":{"value":"value function","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$7DF7AC78-DDD4-4205-95F2-DA6889479BD9","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"d6296affc7ff5718e84879a2b5e477dcec0cb1fd","datavalue":{"value":"optimal synthesis","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$0C355B40-EBBF-4C4A-8B27-56225519DFF6","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"6eb79f83ff15d413749646ab86b5226b5a1a425b","datavalue":{"value":"Cauchy characters","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$FB51ED68-190F-4081-9CA3-2D1E033A1B5E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"18802dfa221025eb9499b88815975049e7c1162e","datavalue":{"value":"Pontryagin maximum principle","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$EFF28673-D2F5-4C1F-AE29-40057C1B16C4","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"e6b8e6a9e363e39269df415c8d3891e3a9ad17c3","datavalue":{"value":"(minimax/viscosity) solutions","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$6CCF9085-AC69-4409-89E7-D9D5E9074C1D","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"77108b9e95115f24ddc8d90afd7e0501990481d5","datavalue":{"value":"Hamilton-Jacobi-Bellmann equation","type":"string"},"datatype":"string"},"type":"statement","id":"Q2317230$8BE0A459-1BC6-403B-A23C-46BF0F5E19C1","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"57f7fea50d2ce1b39b695c4a1313582eed405e38","datavalue":{"value":{"entity-type":"item","numeric-id":5976449,"id":"Q5976449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$E1EAA9A3-E895-46A1-A3A7-F80EDE2B25F1","rank":"normal"}],"P223":[{"mainsnak":{"snaktype":"value","property":"P223","hash":"99cd46e1af0467597dfaf47b6691d1c7614bc9ea","datavalue":{"value":{"entity-type":"item","numeric-id":3545186,"id":"Q3545186"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$20C8DFA5-899D-4CEF-BBE1-7A0F6F3173B4","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"ad8d262b8c68ce82d10918cf5610c82373de636d","datavalue":{"value":{"entity-type":"item","numeric-id":3285813,"id":"Q3285813"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$84A8EB99-9F43-4D3C-91BC-D7DD03CA7353","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"6a860092cae4ad4c5ee631c0a98f0a7ee7f9c9d0","datavalue":{"value":{"entity-type":"item","numeric-id":3241581,"id":"Q3241581"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$304FE036-9439-4C46-A521-4B9C336A0666","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"c2e2573280bc5d2486d5e85a53ad0db80a1202ef","datavalue":{"value":{"entity-type":"item","numeric-id":4053412,"id":"Q4053412"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2317230$E394A61E-5BBC-4AFB-A6E4-76550FE51A38","rank":"normal"}],"P205":[{"mainsnak":{"snaktype":"value","property":"P205","hash":"1800a126e0c91607316699710d1763a20a940fa3","datavalue":{"value":"https://doi.org/10.1134/s008154381901019x","type":"string"},"datatype":"url"},"type":"statement","id":"Q2317230$27C2AB19-809F-43F2-B4BD-BBF0CA6C0BE8","rank":"normal"}],"P388":[{"mainsnak":{"snaktype":"value","property":"P388","hash":"60fd5f3e26c9d1ca065b1bd78ee356577fd24ea1","datavalue":{"value":"W3016225735","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$E1D0BC95-7B01-436E-8AF1-70757DB3E443","rank":"normal"}],"P12":[{"mainsnak":{"snaktype":"value","property":"P12","hash":"50e4ff8c7d4ef10b18965cf729867f57c499167b","datavalue":{"value":"Q127737586","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2317230$000E0F21-6EEE-4754-BA12-67635B8BA6BF","rank":"normal"}],"P1643":[{"mainsnak":{"snaktype":"value","property":"P1643","hash":"cbabcd02a4c70c94d80dea83807bada6cac7b9a5","datavalue":{"value":{"entity-type":"item","numeric-id":326554,"id":"Q326554"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"494e05f88d13ee768ecc616010794edc20378e59","datavalue":{"value":{"amount":"+0.91552454","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"ac3c626774dcd0d16f89557f66586245841a01db","datavalue":{"value":{"entity-type":"item","numeric-id":6767936,"id":"Q6767936"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2317230$D34A704E-0969-4CC2-AE67-724F9251C1B3","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"c80e5f792a55ae5ca69753a24f27c552965baaa5","datavalue":{"value":{"entity-type":"item","numeric-id":1607229,"id":"Q1607229"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"3d59cf9f7da2b43bb4c6c0a4e9b99e1ff4e3ff1a","datavalue":{"value":{"amount":"+0.9131591","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"ac3c626774dcd0d16f89557f66586245841a01db","datavalue":{"value":{"entity-type":"item","numeric-id":6767936,"id":"Q6767936"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2317230$EBDC89A8-A827-4615-A19E-BC761D3924CF","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"a59c60522774f24afb3aad0fc16fcc60a63d81b0","datavalue":{"value":{"entity-type":"item","numeric-id":4726086,"id":"Q4726086"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"ca0b038630a407f2b3f6f5afa9e7402769953469","datavalue":{"value":{"amount":"+0.9130492","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"ac3c626774dcd0d16f89557f66586245841a01db","datavalue":{"value":{"entity-type":"item","numeric-id":6767936,"id":"Q6767936"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2317230$F9FCC9DE-1BE1-4352-A34C-632C455D2C16","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"366c7e5ed39d6e7a39457d8fae40221ecf7c8314","datavalue":{"value":{"entity-type":"item","numeric-id":4459136,"id":"Q4459136"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"515f5b06ea9f394b73a708ba4897ffd5b901ec72","datavalue":{"value":{"amount":"+0.9096898","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"ac3c626774dcd0d16f89557f66586245841a01db","datavalue":{"value":{"entity-type":"item","numeric-id":6767936,"id":"Q6767936"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2317230$972748FF-E9F3-41BC-A6E1-CC8ED1CCC2ED","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"fa256958ec1f6221227b0def0bed16bd5dc81856","datavalue":{"value":{"entity-type":"item","numeric-id":2455569,"id":"Q2455569"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"fc6694443c38f3756d3821ef64d15b2144b2e9b2","datavalue":{"value":{"amount":"+0.9086157","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"ac3c626774dcd0d16f89557f66586245841a01db","datavalue":{"value":{"entity-type":"item","numeric-id":6767936,"id":"Q6767936"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2317230$1A48CB69-3D26-4CF4-BB73-ABDB3213362E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"82561f630c0de1328e50fa738b6456ba1b3a00e5","datavalue":{"value":{"entity-type":"item","numeric-id":3835342,"id":"Q3835342"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"5a03e316d16bf78581432b0328dab5f5a381575d","datavalue":{"value":{"amount":"+0.90818256","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"ac3c626774dcd0d16f89557f66586245841a01db","datavalue":{"value":{"entity-type":"item","numeric-id":6767936,"id":"Q6767936"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2317230$9B79C7E3-0ED6-48BA-A075-24AE7CECC1FD","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"949c0e2d7ad6931485c67ac68dd52b8047115fff","datavalue":{"value":{"entity-type":"item","numeric-id":1813817,"id":"Q1813817"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"2e6a9e455e3dd329b816e64a58166ff09f843ba9","datavalue":{"value":{"amount":"+0.9072978","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"ac3c626774dcd0d16f89557f66586245841a01db","datavalue":{"value":{"entity-type":"item","numeric-id":6767936,"id":"Q6767936"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2317230$B3013EFF-80F2-49A4-ACB6-44AEB254E6E3","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"b6b6193602cec2a2601e7cffa615932ee7a209d6","datavalue":{"value":{"entity-type":"item","numeric-id":3417961,"id":"Q3417961"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"48e746a5b202038a1112e4df6add4fdabe96e7f3","datavalue":{"value":{"amount":"+0.90645427","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"ac3c626774dcd0d16f89557f66586245841a01db","datavalue":{"value":{"entity-type":"item","numeric-id":6767936,"id":"Q6767936"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2317230$43B0A03E-A738-4880-ACC9-84322054CC24","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"863dcf11c916e9a6c247c44223581d3ca49b418c","datavalue":{"value":{"entity-type":"item","numeric-id":603073,"id":"Q603073"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"0b7befaef5115fd7bb941457d25bfaeab4240e2f","datavalue":{"value":{"amount":"+0.904268","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"ac3c626774dcd0d16f89557f66586245841a01db","datavalue":{"value":{"entity-type":"item","numeric-id":6767936,"id":"Q6767936"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2317230$548AC1BE-842D-44DF-92EC-9FF589784E5A","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"Publication:2317230","badges":[]}}}}}