{"entities":{"Q2336643":{"pageid":2347386,"ns":120,"title":"Item:Q2336643","lastrevid":57314559,"modified":"2026-03-30T09:37:12Z","type":"item","id":"Q2336643","labels":{"en":{"language":"en","value":"Birhythmicity and hard excitation from coupled synthetic feedback loops"}},"descriptions":{"en":{"language":"en","value":"scientific article; zbMATH DE number 7131796"}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"fd5912e4dab4b881a8eb0eb27e7893fef55176ad","datavalue":{"value":{"entity-type":"item","numeric-id":56887,"id":"Q56887"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$082ED506-F82A-4CA7-B7B7-87F71823E1B1","rank":"normal"}],"P159":[{"mainsnak":{"snaktype":"value","property":"P159","hash":"f9cd9303bb17f0a686bbd757a8a6aa7b53e6faac","datavalue":{"value":{"text":"Birhythmicity and hard excitation from coupled synthetic feedback loops","language":"en"},"type":"monolingualtext"},"datatype":"monolingualtext"},"type":"statement","id":"Q2336643$AB0784D5-C226-4036-A940-F58BB94243FA","rank":"normal"}],"P225":[{"mainsnak":{"snaktype":"value","property":"P225","hash":"55db3c446d518b8866347ad2cd325b804befae9f","datavalue":{"value":"1442.92048","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2336643$EE21B9FE-70E4-4363-A83E-A1D9A58D49E4","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"13c2a98a2c6f7d8c1236e748666b712795b1f450","datavalue":{"value":"10.1155/2014/694854","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2336643$B1D9D3AE-739E-4A38-9C56-340220B5726C","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"a12f9b6b0763c6a0561edaa6156ca4dfcd211eba","datavalue":{"value":{"entity-type":"item","numeric-id":420071,"id":"Q420071"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$A046495E-15D3-4F14-A0DF-CB337C2D8714","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"fb75e6bb6db44c407a3bedc851153480de0a31d6","datavalue":{"value":{"entity-type":"item","numeric-id":358020,"id":"Q358020"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$6FD05EEF-B7CF-4934-B058-6C18537F3888","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"2a1aa09fc1e1940802be12427e083efc8d65115f","datavalue":{"value":{"entity-type":"item","numeric-id":398386,"id":"Q398386"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$5F2F7757-DB04-4AB1-A015-88AF907B421F","rank":"normal"}],"P200":[{"mainsnak":{"snaktype":"value","property":"P200","hash":"bb299feb2b87699ac8beef494c52fd2765eaf609","datavalue":{"value":{"entity-type":"item","numeric-id":118601,"id":"Q118601"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$CBD2F023-A838-41E2-8A14-CBEAD3DB44DA","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"10393ba55f1a886ba53e75eccd4b56403eff1eb9","datavalue":{"value":{"time":"+2019-11-19T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q2336643$1883197E-23DB-4F6D-868E-64BE627C5995","rank":"normal"}],"P1448":[{"mainsnak":{"snaktype":"value","property":"P1448","hash":"b6d968d8c47ddb94cfce1c6ef0974e1b51fb20ab","datavalue":{"value":"Summary: Synthetic biology opens up the possibility of creating circuits that would not survive in the natural world and studying their behaviors in living cells, expanding our notion of biology. Based on this, we analyze on a synthetic biological system the effect of coupling between two instability-generating mechanisms. The systems considered are two topologically equivalent synthetic networks. In addition to simple periodic oscillations and stable steady state, the system can exhibit a variety of new modes of dynamic behavior: coexistence between two stable periodic regimes (birhythmicity) and coexistence of a stable periodic regime with a stable steady state (hard excitation). Birhythmicity and hard excitation have been proved to exist in biochemical networks. Through bifurcation analysis on these two synthetic cellular networks, we analyze the function of network structure for the collapse and revival of birhythmicity and hard excitation with the variation of parameters. The results have illustrated that the bifurcation space can be divided into four subspaces for which the dynamical behaviors of the system are generically distinct. Our analysis corroborates the results obtained by numerical simulation of the dynamics.","type":"string"},"datatype":"string"},"type":"statement","id":"Q2336643$729C31E9-0948-4613-80E2-AD6D938D5B22","rank":"normal"}],"P226":[{"mainsnak":{"snaktype":"value","property":"P226","hash":"1cc6a2d1a81aec0cb5abdfe44055f934ac25329b","datavalue":{"value":"92C40","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2336643$BAA63E77-8DBF-4262-B645-4D0DF540F4AB","rank":"normal"}],"P1451":[{"mainsnak":{"snaktype":"value","property":"P1451","hash":"9e085ec92e517a4635715e9bb922212c7d7cf9d0","datavalue":{"value":"7131796","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2336643$8EEA5494-A7BA-4294-AFCB-7F744117437A","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"57f7fea50d2ce1b39b695c4a1313582eed405e38","datavalue":{"value":{"entity-type":"item","numeric-id":5976449,"id":"Q5976449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$46BDCE6E-6400-407B-BCF3-0D8D6BE7B334","rank":"normal"}],"P205":[{"mainsnak":{"snaktype":"value","property":"P205","hash":"f09cf1a11deee101950916d4033cf5cc94f825ea","datavalue":{"value":"https://doi.org/10.1155/2014/694854","type":"string"},"datatype":"url"},"type":"statement","id":"Q2336643$901D1186-06B5-424F-91E5-DB9A25FB5C84","rank":"normal"}],"P388":[{"mainsnak":{"snaktype":"value","property":"P388","hash":"6633972a57554cbdc735cae13cfd222ef50c5446","datavalue":{"value":"W2044176577","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2336643$E1CB3366-F12C-4981-93AA-3D515383EB23","rank":"normal"}],"P12":[{"mainsnak":{"snaktype":"value","property":"P12","hash":"4c446f19ff034a5f4fc15d551e8d3f281c581e74","datavalue":{"value":"Q59054085","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q2336643$F2EEB719-2753-4932-B83C-57F66298D130","rank":"normal"}],"P223":[{"mainsnak":{"snaktype":"value","property":"P223","hash":"90342f0f43336c35fc2f33fa5816935de4097807","datavalue":{"value":{"entity-type":"item","numeric-id":5549555,"id":"Q5549555"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$2264408B-8483-40F9-9924-3D0726075124","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"cfb5a4e9f1c6515b3d4e8a0e4ca14b97a1099129","datavalue":{"value":{"entity-type":"item","numeric-id":3895289,"id":"Q3895289"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$D06C96C4-F975-4AFB-954F-E1DDE02AD8AE","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"e45b6547cdfa53f3bfe0a1e76a0ebc5eb0475cf1","datavalue":{"value":{"entity-type":"item","numeric-id":1346417,"id":"Q1346417"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$64530BC9-4CC5-4F6A-BC6C-BF5C3AE28D44","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"3fdb5e737d50e53c79de912221e2a2d9ddeded96","datavalue":{"value":{"entity-type":"item","numeric-id":3953600,"id":"Q3953600"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$9C663CB6-EDAD-493D-A7E9-EB9D22A588E1","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"d40625b1a4182740b2cc2bd9f146b6e87dfbc08e","datavalue":{"value":{"entity-type":"item","numeric-id":4856151,"id":"Q4856151"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$FFFAF290-CFED-4E06-8578-0CCA924420A4","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"3e09abf932a09813376c3be4862e9ca7855ad8ed","datavalue":{"value":{"entity-type":"item","numeric-id":886676,"id":"Q886676"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$FCBF8C7F-6483-4D6C-9E4D-D5D95D5BFBC2","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"a6ed1c61cba0791f8439e2590ff441f51f5e88cc","datavalue":{"value":{"entity-type":"item","numeric-id":4652651,"id":"Q4652651"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$2D2A0F04-36E9-4EE6-8DAD-A2899C9EC7E8","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"07aff01d38ad7fc08e0ce086c9734b74c5c53e1a","datavalue":{"value":{"entity-type":"item","numeric-id":5460846,"id":"Q5460846"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$7FF0F851-760F-44ED-988B-AFD40F6C0A9C","rank":"normal"}],"P1643":[{"mainsnak":{"snaktype":"value","property":"P1643","hash":"2d9b875049e5f8afdaeec5a4b349ec419c141c4b","datavalue":{"value":{"entity-type":"item","numeric-id":765007,"id":"Q765007"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"d72d86a4ef16c23e9c859b99b9dae06fbb0b9a8d","datavalue":{"value":{"amount":"+0.7276250123977661","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2336643$C7283924-BE31-4B51-8CF0-E08E907AFF49","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"be0605b50efaa383d30b597ab1c024b008acc0d8","datavalue":{"value":{"entity-type":"item","numeric-id":5140897,"id":"Q5140897"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"6e229686fd00386a337c4635bfafda40c3b5f47c","datavalue":{"value":{"amount":"+0.7254875898361206","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2336643$9767EBD5-B9B3-42A3-A5D8-85FFB314CEA6","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"23d745bbc7c4e162b65c9641a147220e8e03a53b","datavalue":{"value":{"entity-type":"item","numeric-id":2843550,"id":"Q2843550"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"285b2eb48d6dddd38d42305007ebef3eee0443d0","datavalue":{"value":{"amount":"+0.7237159013748169","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2336643$86B2B091-2C1E-40E0-915A-5FB688881DAC","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"6c0d127d4d0ad93d3e69823d53f2ff1a5514b235","datavalue":{"value":{"entity-type":"item","numeric-id":2940323,"id":"Q2940323"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"ebde4466fd3feec895ed879258f80995c9be8898","datavalue":{"value":{"amount":"+0.7191330194473267","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2336643$59C48AFC-CC96-430A-9C51-EE6FDFB101F0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"78cd227eb34a3972321077d627ef9b4f20a80629","datavalue":{"value":{"entity-type":"item","numeric-id":2787760,"id":"Q2787760"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"c6ca9a7087dd2fd445fd0062a93bb5cd5f670185","datavalue":{"value":{"amount":"+0.7065759301185608","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q2336643$BFF5FB80-9DA3-4E19-AA49-42321EE0B2CB","rank":"normal"}],"P163":[{"mainsnak":{"snaktype":"value","property":"P163","hash":"daf5f856a5d861312ad309ab567540337a5f61d6","datavalue":{"value":{"entity-type":"item","numeric-id":57050,"id":"Q57050"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q2336643$E3089936-F204-42DD-BADF-44AB3810FC88","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"Publication:2336643","badges":[],"url":"https://portal.mardi4nfdi.de/wiki/Publication:2336643"}}}}}