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The authors consider such operator in two different but related contexts: a quantum mechanical and a stochastic contex.  In the quantum mechanical model, \\(H\\) describes the Hamiltonian of a particle subject to a potential \\(V\\) and the dynamics is governed by the Schr\u00f6dinger's equation  \\[  i\\partial_tu(x,t)=Hu(x,t)\\,,\\;\\;\\;u(\\cdot,0)=u_0.  \\]  In this case, existence and uniqueness of a solution preserving the weighted \\(L^2_{\\rho_{\\infty}}\\)-norm is equivalent to the essential self-adjointness of \\(H\\).  In the stochastic model, \\(H\\) generates the Fokker-Plank dynamics of the system (after a suitable symmetrization). The authors consider in this context only the case \\(V=0\\), i.e., the equation  \\[  \\partial_t\\mu(x,t)=-H_0\\mu(x,t)\\,,\\;\\;\\;\\mu(\\cdot,0)=\\mu_0,  \\]  where \\(H_0=H\\) with \\(V\\equiv0\\). Existence and uniqueness of a non-negative solution preserving the \\(L^1_{\\rho_{\\infty}}\\)-norm is called stochastic completeness. In this case one has to show that the Friedrichs extension of \\(H_0\\) is conservative.  The authors give several sufficient conditions under which \\(H\\) is essentially self-adjoint and \\(H_0\\) is stochastically complete. In particular, such conditions are given in two different forms: in terms of the Riemannian metric and in terms of the Euclidean metric.  In the first case (the Riemannian setting), the authors consider the domain \\(\\Omega\\) endowed with a Riemannian metric given in terms of \\(\\mathbb D^{-1}\\) and the measure \\(\\rho_{\\infty}(x)dx\\). Therefore the study of \\(H,H_0\\) is recast into the study of a weighted Laplace-Beltrami operator. They give criteria for essential self-adjointness for \\(H\\) (Theorem 4.1) and stochastic completeness for \\(H_0\\) (Theorem 4.2) in terms of the geometry of the manifold \\((\\Omega,\\mathbb D^{-1},\\rho_{\\infty}(x)dx)\\).  In the second case (Euclidean setting), the authors give more explicit sufficient conditions for essential self-adjointness for \\(H\\) (Theorem 5.1) and stochastic completeness for \\(H_0\\) (Theorem 5.3) in terms of the behavior of the coefficients near the boundary of the 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