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Define the total cofiber \\(\\Gamma(X)\\) of a diagram \\(X:\\mathcal{C}\\to\\mathcal{SS}ets_\\ast\\) of pointed simplicial sets as the strict cofiber of the map \\(\\text{hocolim}_{\\mathcal D}(X)\\to \\text{hocolim}_{\\mathcal C}(X)\\). Analogously, the total cofiber of a diagram of pointed topological spaces is defined. By applying the definition levelwise, we obtain a total cofiber functor for diagrams of spectra in the sense of \\textit{A. K. Bousfield} and \\textit{E. M. Friedlander} [Geom. Appl. Homotopy Theory, II, Proc. Conf., Evanston 1977, Lect. Notes Math. 658, 80-130 (1978; Zbl 0405.55021)]. The total cofiber functor has been used by the author in his studies of quasi-coherent sheaves on projective toric varieties as a replacement of the global section functor and its derived functors. If \\(\\mathcal{C}\\) is the poset of non-empty faces of a polytope and \\(\\mathcal{D}\\) the subposet of proper faces and \\(X\\) is a \\(\\mathcal{C}\\)-diagram of pointed spaces the author constructed a spectral sequence  \\[  E^2_{p,q}= \\lim{}^{n-p}\\widetilde{H}_q(X;\\mathbb{Z})\\to \\widetilde{H}_{p+q}(\\Gamma(X);\\mathbb{Z})  \\]  where \\(n\\) is the dimension of the polytope [\\textit{T. H\u00fcttemann}, K-Theory 31, 101--123 (2004; Zbl 1068.55015)]. This spectral sequence can be interpreted as a device for comparing the homotopy limit of \\(X\\) with the total cofiber. The present paper investigates this relationship more closely. For a diagram \\(X\\) of pointed spectra the author constructs a map  \\[  \\widetilde{\\Gamma}_X:\\text{holim}_{\\mathcal C}X\\to \\Hom_{\\mathcal{SS}ets_\\ast} (\\Gamma(N(\\mathcal{C}\\downarrow -)_+), \\widetilde{\\Gamma}(X))  \\]  from the homotopy limit into a mapping space and characterizes all pairs of posets \\(\\mathcal{D}\\subset\\mathcal{C}\\) for which \\(\\widetilde{\\Gamma}_Y\\) is a stable weak equivalence of spectra. Here \\(N\\) is the nerve functor and \\(\\tilde{\\Gamma}(Y)\\) is the levelwise fibrant replacement of \\(\\Gamma(X)\\). 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