{"entities":{"Q382618":{"pageid":384385,"ns":120,"title":"Item:Q382618","lastrevid":61456119,"modified":"2026-04-10T23:29:30Z","type":"item","id":"Q382618","labels":{"en":{"language":"en","value":"An empirical Bayes optimal discovery procedure based on semiparametric hierarchical mixture models"}},"descriptions":{"en":{"language":"en","value":"scientific article; zbMATH DE number 6231260"}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"fd5912e4dab4b881a8eb0eb27e7893fef55176ad","datavalue":{"value":{"entity-type":"item","numeric-id":56887,"id":"Q56887"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$509392A4-5DBD-426E-83D9-CC81B6D74CEC","rank":"normal"}],"P159":[{"mainsnak":{"snaktype":"value","property":"P159","hash":"727fa397e3621e2589b10990084ca5f647bfa524","datavalue":{"value":{"text":"An empirical Bayes optimal discovery procedure based on semiparametric hierarchical mixture models","language":"en"},"type":"monolingualtext"},"datatype":"monolingualtext"},"type":"statement","id":"Q382618$C90618FF-ED0B-4E3F-B208-B93C099DD281","rank":"normal"}],"P225":[{"mainsnak":{"snaktype":"value","property":"P225","hash":"30838031778457e21c4203a281d8b8b6f1b5628b","datavalue":{"value":"1275.92074","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q382618$B3BD41B5-0629-4EB8-A814-A13C1D217677","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"756c156b41a1c883cda1f55b2aefaee62aebe116","datavalue":{"value":"10.1155/2013/568480","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q382618$61BBCF35-1A31-43EB-8942-B2954731A07C","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"b4b23102ec2a031faaa6c40c17d0a1328c99ab63","datavalue":{"value":{"entity-type":"item","numeric-id":382617,"id":"Q382617"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$2DEA1EC9-E978-4569-A6C6-48F8762D71F9","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"fbb45610e1c02d8fc9e6e513204cb4affdcb40b6","datavalue":{"value":{"entity-type":"item","numeric-id":61636,"id":"Q61636"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$F590FDAE-6C5C-4E92-BE35-5662B64E9D99","rank":"normal"}],"P200":[{"mainsnak":{"snaktype":"value","property":"P200","hash":"ae2a137607979ebaa11579b7aa87d8ebbaf2710b","datavalue":{"value":{"entity-type":"item","numeric-id":278087,"id":"Q278087"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$02D3D137-DE75-4731-AA35-7DFE3DFFA51F","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"cdd4a751ba4fdcf728e9ea46a31d246e59bdb21f","datavalue":{"value":{"time":"+2013-11-21T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q382618$940BDDCE-12F4-4175-9EF3-619CAD5C5B59","rank":"normal"}],"P1448":[{"mainsnak":{"snaktype":"value","property":"P1448","hash":"3593fcde4342d8264017c8a91a5ac273675d8200","datavalue":{"value":"Summary: Multiple testing has been widely adopted for genome-wide studies such as microarray experiments. For effective gene selection in these genome-wide studies, the optimal discovery procedure (ODP), which maximizes the number of expected true positives for each fixed number of expected false positives, was developed as a multiple testing extension of the most powerful test for a single hypothesis by \\textit{J. D. Storey} [``The optimal discovery procedure: a new approach to simultaneous significance testing``, J. R. Stat. Soc., Ser. B, Stat. Methodol. 69, No. 3, 347--368 (2007; \\url{doi:10.1111/j.1467-9868.2007.005592.x})]. In this paper, we develop an empirical Bayes method for implementing the ODP based on a semiparametric hierarchical mixture model using the ``smoothing-by-roughening'' approach. Under the semiparametric hierarchical mixture model, (i) the prior distribution can be modeled flexibly, (ii) the ODP test statistic and the posterior distribution are analytically tractable, and (iii) computations are easy to implement. In addition, we provide a significance rule based on the false discovery rate (FDR) in the empirical Bayes framework. Applications to two clinical studies are presented.","type":"string"},"datatype":"string"},"type":"statement","id":"Q382618$A312765F-BF45-4231-BB52-2F31D66C294F","rank":"normal"}],"P226":[{"mainsnak":{"snaktype":"value","property":"P226","hash":"8acfb5681686a479769f1498162f25169e468cda","datavalue":{"value":"92D10","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q382618$CFA6FA96-73A3-4DAD-965D-1B96FC445E88","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"3d678e3814c9d242125a70d49a616f736949e344","datavalue":{"value":"62F03","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q382618$38555966-A60D-4784-9F27-E09E17DCEF99","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"708a6f1a75f978962215fcdf6748c16c77f4fd6e","datavalue":{"value":"62P10","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q382618$649A666C-D41C-4E32-9D50-BBBEF8A60D15","rank":"normal"}],"P1451":[{"mainsnak":{"snaktype":"value","property":"P1451","hash":"c669f86759daf6a7681ed45bb41ea8b197aa21d7","datavalue":{"value":"6231260","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q382618$776C0FB7-6090-47DE-A746-C882D125ABF1","rank":"normal"}],"P12":[{"mainsnak":{"snaktype":"value","property":"P12","hash":"c68d3ae540397efa2cff7912c0e55f9ef503f36f","datavalue":{"value":"Q40566390","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q382618$CE51B513-D680-445A-A409-5232C30205DA","rank":"normal"}],"P1463":[{"mainsnak":{"snaktype":"value","property":"P1463","hash":"bf7b8c24e48a9e503f7e33fffe0411e19bb82ca5","datavalue":{"value":{"entity-type":"item","numeric-id":25023,"id":"Q25023"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$5553402A-7B1E-456D-A5EE-C334004E6A6E","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"57f7fea50d2ce1b39b695c4a1313582eed405e38","datavalue":{"value":{"entity-type":"item","numeric-id":5976449,"id":"Q5976449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$E2DE26E9-407B-4C5B-976C-B7B515EAD603","rank":"normal"}],"P205":[{"mainsnak":{"snaktype":"value","property":"P205","hash":"4d4df1d90d38e188d3f55e039680c1e940e7da98","datavalue":{"value":"https://doi.org/10.1155/2013/568480","type":"string"},"datatype":"url"},"type":"statement","id":"Q382618$3F564628-8AA7-42ED-A451-BBC10FB41F36","rank":"normal"}],"P388":[{"mainsnak":{"snaktype":"value","property":"P388","hash":"e5f03e9e191be87ac3e56b2b41eb1b20f09abcc8","datavalue":{"value":"W2017687404","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q382618$614CA3EF-89B6-464D-B0D9-D565B322B63C","rank":"normal"}],"P223":[{"mainsnak":{"snaktype":"value","property":"P223","hash":"6564b048d491345d98db75f26b262c87ee466dc4","datavalue":{"value":{"entity-type":"item","numeric-id":1420352,"id":"Q1420352"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$401DA5FC-08AB-4A61-9226-1313CAA92E04","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"ba8ff8e68cd0d2ac17ea1e112b76dc19d37393df","datavalue":{"value":{"entity-type":"item","numeric-id":3566620,"id":"Q3566620"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$03AA39AC-758E-41C9-9858-EEAB067CFEA8","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"7bdb4af6795b5be64af27198c893072065141483","datavalue":{"value":{"entity-type":"item","numeric-id":4322338,"id":"Q4322338"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$F092F770-8B91-4ED2-ABBE-879F3EB63BA8","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"ff013245bf6f079195647a7d6d91092b5e6a57c8","datavalue":{"value":{"entity-type":"item","numeric-id":4665895,"id":"Q4665895"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$95C0095C-1D45-4C16-BCD0-52FF216FBCBF","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"0c45b12007f260fc31219b4c01e213d06a8db942","datavalue":{"value":{"entity-type":"item","numeric-id":1430922,"id":"Q1430922"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$46EAE8A9-13BA-4A6B-A0DA-C85C23C100A7","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"4da7b04a3cc669d2b28bf514b04c299a40529f8c","datavalue":{"value":{"entity-type":"item","numeric-id":4752191,"id":"Q4752191"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$369E746F-81B7-44BB-BD43-FF340C99486E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"d4567626b0fe2cade7d60bc738282b3e97dabc95","datavalue":{"value":{"entity-type":"item","numeric-id":3592122,"id":"Q3592122"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$A23520AE-551D-430C-9F1E-3C8E1C2EF42D","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"412faeebff884147142717d54b5db4ed7adc6efc","datavalue":{"value":{"entity-type":"item","numeric-id":3747485,"id":"Q3747485"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$BA87E479-B74F-4905-ABB8-2737E6B28AAA","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"692b65af57e558d29e588e4202d2a6bfe6dbdfa4","datavalue":{"value":{"entity-type":"item","numeric-id":5701226,"id":"Q5701226"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$CE294E59-26E0-4FF3-B951-A546BF39A036","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"96c902900472fcbdd451229961fd8d09345197f9","datavalue":{"value":{"entity-type":"item","numeric-id":4532837,"id":"Q4532837"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$35EF1BEC-C5DD-4620-B99F-BE33EC8C733D","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"171bc59480d2e0b03274d360f15f0497fa23776b","datavalue":{"value":{"entity-type":"item","numeric-id":1896163,"id":"Q1896163"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$E8E2770B-F255-4004-8F59-B8E890DFCB86","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"44c5b4cc0708db8ae610a3e67f8f2a2bd4978fea","datavalue":{"value":{"entity-type":"item","numeric-id":3237829,"id":"Q3237829"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$53E7C7B3-FF96-4E2C-88E8-BE1794E0C1F1","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"993fb82e7a0e72e44ee730eec41b80e5ea14745e","datavalue":{"value":{"entity-type":"item","numeric-id":1159929,"id":"Q1159929"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$6F471CA0-CAFD-40B3-BBFD-CDC47C25EF61","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"d16aaf7d5798cc1d9088edb5c91f2d7622e7e038","datavalue":{"value":{"entity-type":"item","numeric-id":5639150,"id":"Q5639150"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$B2F83F3F-875E-43F4-B3DC-35CDB2EF1499","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"57ad71712df5f5788bca418eb98334cf5d197ebc","datavalue":{"value":{"entity-type":"item","numeric-id":4082142,"id":"Q4082142"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$9FB5C324-A147-4169-805D-334DCB20F29C","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"3d82d984c5ca8f250ee8364245314ef8125e60e6","datavalue":{"value":{"entity-type":"item","numeric-id":4743564,"id":"Q4743564"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$CEC69F84-4520-4B63-9624-72DEA4F81EAA","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"3b468862839979e3a4c468f579301e8b1540c8d3","datavalue":{"value":{"entity-type":"item","numeric-id":4172788,"id":"Q4172788"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$5C84BA12-F6E7-43C8-A8B5-49C2180CBCBB","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"5843906d458cc9ce5e3285e343e2850a7da598f8","datavalue":{"value":{"entity-type":"item","numeric-id":3963871,"id":"Q3963871"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$D74AA3EA-B51C-43CC-BB2B-D493A9E72D07","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"f07818b634e459fdfbede08defa40c8e8ef26894","datavalue":{"value":{"entity-type":"item","numeric-id":4139463,"id":"Q4139463"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$4F37FD4D-A8C9-4FC8-9889-C07441D23955","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"b869dc95e66f0bc1513108478703b907ccb20266","datavalue":{"value":{"entity-type":"item","numeric-id":5701280,"id":"Q5701280"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$0CD1238F-1F3E-4C3F-A2C6-79BB8AD9DF80","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"021a91e30e5d8eeb25dd22596593e63704f91201","datavalue":{"value":{"entity-type":"item","numeric-id":2456004,"id":"Q2456004"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$0F516FC0-4F7A-45DE-9DC4-93B486E6128B","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"494905d30d89df374c58ccfd703731d9b29f319d","datavalue":{"value":{"entity-type":"item","numeric-id":900479,"id":"Q900479"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$AA587859-1E6D-418F-992E-C3AAE1E1C98C","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"6f8a2a14bfcbde6956e173b168ad2f0f253bb181","datavalue":{"value":{"entity-type":"item","numeric-id":2893379,"id":"Q2893379"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q382618$6CE0722D-8598-41BE-B033-0E232FA44923","rank":"normal"}],"P1635":[{"mainsnak":{"snaktype":"value","property":"P1635","hash":"4891e2fd23bde48b3405fbb747c1d94a89b4f3f9","datavalue":{"value":"journals/cmmm/NomaM13","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q382618$002AB7F4-9D61-495D-BA69-53153E176F74","rank":"normal"}],"P1643":[{"mainsnak":{"snaktype":"value","property":"P1643","hash":"f3aa5fdbd3bd4fb82e6b332b1333186111514e93","datavalue":{"value":{"entity-type":"item","numeric-id":4632611,"id":"Q4632611"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"397479da6dd5036c999585632e4766b8004792f6","datavalue":{"value":{"amount":"+0.8267562985420227","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q382618$308DED23-3385-49B6-BE62-79A737144725","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"bd3a5a82000ef43ef56232630d2d59f4a1dfe61c","datavalue":{"value":{"entity-type":"item","numeric-id":3592122,"id":"Q3592122"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"6f26802142dbad775ead406f7e8ce6475e8fea99","datavalue":{"value":{"amount":"+0.8200835585594177","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q382618$2F5DC2FE-C10B-487A-8510-9AB60EE5D28B","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"908ea94b49f2d9abe5d0f3e21c2ffa0011f53ce0","datavalue":{"value":{"entity-type":"item","numeric-id":3514414,"id":"Q3514414"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"aaa4ac3b8bddd8d595a92f5bdd370c6e37df115e","datavalue":{"value":{"amount":"+0.8015261888504028","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q382618$68111E59-3942-4F25-BE0D-213E9DE1335E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"2edc38f62d667f0e9b8f16dea2633e4b3ca2eafc","datavalue":{"value":{"entity-type":"item","numeric-id":1927225,"id":"Q1927225"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"b092eff76a7a08ee005b2af53b482310702938e9","datavalue":{"value":{"amount":"+0.8006330132484436","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q382618$62F71D18-44A6-4A1B-B1FA-815C1454ED56","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"736773219094f234352ba29b7c299e561dc9387c","datavalue":{"value":{"entity-type":"item","numeric-id":2903318,"id":"Q2903318"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"68f58e663a9a26aa6ca49189eacd662f04850560","datavalue":{"value":{"amount":"+0.7746723294258118","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q382618$40A4492D-0BCE-443F-AE29-1E11D123BF1D","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"An empirical Bayes optimal discovery procedure based on semiparametric hierarchical mixture models","badges":[],"url":"https://portal.mardi4nfdi.de/wiki/An_empirical_Bayes_optimal_discovery_procedure_based_on_semiparametric_hierarchical_mixture_models"}}}}}