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It includes the simultaneous measurements of 11 phosphorylated proteins and phospholipids derived from thousands of individual primary immune system cells, subjected to both general and specific molecular interventions.  Task: The dataset can be used to study causal discovery algorithms.  Summary:  Size of collection: 14 datasets on 11 features and 707 to 927 observations Task: Causal Discovery Problem Data Type: Continuous Data Dataset Scope: Collection of Datasets Ground Truth: Known Graph Temporal Structure: Static Data License: CC BY 4.0 (granted by G. Nolan and D. Lauffenburger) Missing Values: No Missing Data   Missingness Statement: There are no missing values.  Features: Each sample in each dataset consists of quantitative amounts of each of the following 11 phosphorylated molecules, simultaneously measured from single cells:    Measured molecule Antibody specificity     Raf Phosphorylation at S259   Erk1 and Erk2 Phosphorylation at T202 and Y204   P38 Phosphorylation at T180 and Y182   Jnk Phosphorylation at T183 and Y185   Akt. Phosphorylation at S473   Mek 1 and Mek2 Phosphorylation at S217 and S221   PKA substrates Detects proteins and peptides containing a phospho-Ser/Thr residue with arginine at the -3 position   PKC Detects phosphorylated PKC-, -I, -II, -, -\u03f5, -, and - isoforms only at C-terminal residue homologous to S660 of PKC-II   Plcg Phosphorylation at Y783   PIP2 Detects PIP2   PIP3 Detects PIP3     Files: The datasets were collected after a series of stimulatory cues and inhibitory interventions, with cell reactions stopped at 15 minutes after stimulation by fixation, to profile the effects of each condition on the intracellular signaling networks of human primary nave CD4+ T cells, downstream of CD3, CD28, and LFA-1 activation.The following conditions were used:    File Stimulation Description     cd3cd28.csv CD3, CD28 T cell activation   cd3cd28icam2.csv CD3, CD28, ICAM-2 LFA-1 signaling induction   cd3cd28_aktinhib.csv CD3, CD28, akt-inhibitor PKA activation   cd3cd28_g0076.csv CD3, CD28, G0076 AKT inhibition   cd3cd28_psitect.csv CD3, CD28, Psitectorigenin MEK1/MEK2 inhibition   cd3cd28_u0126.csv CD3, CD28, U0126 PKC activation   cd3cd28_ly.csv CD3, CD28, LY294002 PKC inhibition   pma.csv PMA PIP2 production inhibition   b2camp.csv 2camp AKT inhibition   cd3cd28icam2_aktinhib.csv CD3, CD28, ICAM-2, akt-inhib simulated dataset   cd3cd28icam2_g0076.csv CD3, CD28, ICAM-2, G0076 simulated dataset   cd3cd28icam2_psit.csv CD3, CD28, ICAM-2, Psitectorigenin simulated dataset   cd3cd28icam2_u0126.csv CD3, CD28, ICAM-2, U0126 simulated dataset   cd3cd28icam2_ly.csv CD3, CD28, ICAM-2, LY294002 simulated dataset     Ground_Truth.csv: Directed Graph derived in Sachs et al. 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