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The NS-HMM is used as a compact, parametric model, generalized from the stationary-state HMM, for describing clean speech statistics in the construction of the minimum mean-square-error (MMSE) speech enhancement system. The feature selection problem associated with the use of the NS-HMM in designing the speech enhancement system is addressed. The MMSE formulation is derived where the NS-HMM is used as the clean speech model and Gaussian-mixture, stationary-state HMM as the additive noise model. Speech enhancement experiments are conducted, demonstrating superiority of the NS-HMM over the stationary-state HMM in the speech enhancement performance for low SNRs. 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