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L. Dayneka, V. Garg} and \\textit{W. J. Jusko} [``Comparison of four basic models of indirect pharmacodynamic responses'', Journal of Pharmacokinetics and Pharmacodynamics 21, No. 4, 457--478, (1993, \\url{doi:10.1007/BF01061691})]. The monotonicity of the time to peak response \\(T_{\\max }\\) with respect to the drug dose \\(D\\) is analysed. The authors consider the situation when the drug is supplied through an initial bolus, and eliminated according to a single exponential function and stimulation or inhibition takes place through a Hill function. 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