{"entities":{"Q6690260":{"pageid":14409241,"ns":120,"title":"Item:Q6690260","lastrevid":54735608,"modified":"2026-01-29T20:21:38Z","type":"item","id":"Q6690260","labels":{"en":{"language":"en","value":"Predicting incremental and future visual change in neovascular age-related macular degeneration using deep learning"}},"descriptions":{"en":{"language":"en","value":"Dataset published at Zenodo repository."}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"dae155fd0809a7906855cd4fa50dd7d71bed552b","datavalue":{"value":{"entity-type":"item","numeric-id":56885,"id":"Q56885"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6690260$EB0FBA51-FA55-492A-8490-97FBE70440F0","rank":"normal"}],"P1459":[{"mainsnak":{"snaktype":"value","property":"P1459","hash":"747889b5488177a92c2a6dbe09c654c7d56f8813","datavalue":{"value":"Purpose To evaluate the predictive utility of quantitative imaging biomarkers, acquired automatically from optical coherence tomography (OCT) scans, of cross-sectional and future visual outcomes of patients with neovascular age-related macular degeneration (AMD) starting anti-vascular endothelial growth factor (VEGF) therapy.  Design Retrospective cohort study.  Methods\u00a0Automatic segmentation was carried out by applying a deep learning segmentation algorithm to 137,379 OCT scans from 6467 eyes of 3261 patients with neovascular AMD between 2007 and 2017 at Moorfields Eye Hospital (a large, UK single-centre). Treatment-na\u00efve, first-treated eyes were taken forward for analysis - 926 eyes of 926 patients. Main outcome measures were correlation coefficients (R2) and mean absolute error (MAE) between quantitative OCT (qOCT) parameters and cross-sectional visual-function; VA at distant timepoints (up to 12 months post-baseline); the incremental VA-change from an individual injection.  Results\u00a0VA at distant timepoints could be predicted: R2 0.79 (MAE 5.0 ETDRS letters) and R2 0.63 (MAE 7.2) post-injection 3 and at 12 months post-baseline (both p  0.001), respectively. Best performing models included both baseline qOCT parameters and treatment-response. Furthermore, we present proof-of-principle evidence that the incremental change in VA from an injection can be predicted: R2 0.13 (MAE 5.6) for injection 2 and R2 0.07 (MAE 5.0) for injection 3 (both p  0.01).  Conclusions\u00a0Automatic segmentation enables rapid acquisition of quantitative and reproducible OCT biomarkers with potential to inform treatment decisions in the care of neovascular AMD. This furthers development of point-of-care decision-aid systems for personalized medicine.","type":"string"},"datatype":"string"},"type":"statement","id":"Q6690260$A31FC9C8-0356-4C0E-842E-1E97DA148C27","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"8d6a456e0bab179ca64e4b2223a94b5349f4a541","datavalue":{"value":{"time":"+2021-02-04T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q6690260$08E341D2-7D43-4F3E-967E-C24D9C408A94","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"d17f7b401b50ff82fe773fe2490279952021a935","datavalue":{"value":{"entity-type":"item","numeric-id":132234,"id":"Q132234"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6690260$EEB74FCC-E545-42F9-8D81-491DB3491BF5","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"5e05e4a90890b1b26dcfe19bab49b441a5536a8f","datavalue":{"value":{"entity-type":"item","numeric-id":132248,"id":"Q132248"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6690260$EA2B505A-C745-4BFC-9209-728F91BF95F5","rank":"normal"}],"P227":[{"mainsnak":{"snaktype":"value","property":"P227","hash":"85c5ce833e9bc0b37a05a93b6e3b1ab5cc74a0f4","datavalue":{"value":"4509402","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q6690260$4480DB33-7B81-40D8-98A2-59940C466883","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"ada46abcd28f8c7e94359ae60a7ecfd5a9c49cc1","datavalue":{"value":"10.5281/zenodo.4509402","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q6690260$492A16FA-2B62-421B-8EEF-5327B8C43F76","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"d1e8073b72a070520efd3d14d4b3d2d3d03859e2","datavalue":{"value":{"entity-type":"item","numeric-id":5984635,"id":"Q5984635"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6690260$A7855D9F-E4BF-4B3B-BE0E-EE118155A7F2","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"Predicting incremental and future visual change in neovascular age-related macular degeneration using deep learning","badges":[],"url":"https://portal.mardi4nfdi.de/wiki/Predicting_incremental_and_future_visual_change_in_neovascular_age-related_macular_degeneration_using_deep_learning"}}}}}