{"entities":{"Q6694831":{"pageid":14413809,"ns":120,"title":"Item:Q6694831","lastrevid":54640625,"modified":"2026-01-29T18:51:05Z","type":"item","id":"Q6694831","labels":{"en":{"language":"en","value":"Comprehensive Multimodal Immune Response Dataset for LAIV Vaccination in Pediatric Cohorts"}},"descriptions":{"en":{"language":"en","value":"Dataset published at Zenodo repository."}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"dae155fd0809a7906855cd4fa50dd7d71bed552b","datavalue":{"value":{"entity-type":"item","numeric-id":56885,"id":"Q56885"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6694831$D28019B0-38DB-4048-80A8-45ADDEC807FF","rank":"normal"}],"P1459":[{"mainsnak":{"snaktype":"value","property":"P1459","hash":"b21402dcfadccb4c56eca7656de5a8191ece84fa","datavalue":{"value":"This dataset is part of the publication \"Integrative Mapping of Pre-existing Immune Landscapes for Vaccine Response Prediction\". It provides detailed immune profiling of 244 children from The Gambia who received the trivalent live attenuated influenza vaccine (LAIV, Nasovac-S) during the 20162017 and 20172018 influenza seasons. It integrates multi-dimensional immune parameters across baseline and post-vaccination timepoints (day 0, day 2, day 7, and day 21) to capture individual immunogenicity profiles. The dataset includes:  Humoral immune responses: Haemagglutination inhibition (HAI) assays, influenza virus protein microarray (IVPM), antibody-dependent cellular cytotoxicity (ADCC) activity, and enzyme-linked immunosorbent assay (ELISA) data for IgA and IgG levels. These measurements assess responses to vaccine-matched and cross-reactive influenza strains, including H1N1, H3N2, and B/Victoria. Cellular immune responses: T-cell cytokine production (e.g., interferon-gamma (IFN-) and interleukin-2 (IL-2)) measured via intracellular cytokine staining (ICS) following stimulation with hemagglutinin (HA), neuraminidase (NA), nucleoprotein (NP), and matrix (M) protein peptides. Viral shedding and microbiome analysis: Viral load quantification by reverse-transcription PCR (RT-PCR) for vaccine strains (H1N1, H3N2, and Flu B) and nasopharyngeal microbiome profiling focusing on Streptococcus pneumoniae density. Immunophenotyping: Flow cytometry data on innate and adaptive immune cell subsets, including myeloid dendritic cells (mDCs), plasmacytoid dendritic cells (pDCs), monocyte subsets (classical, intermediate, and non-classical), and T follicular helper (Tfh) cells. Transcriptomics: RNA-sequencing (RNA-seq) data from nasal and blood samples, providing transcriptomic profiles analyzed through gene set enrichment analysis (GSEA).  This dataset offers a unique resource for studying LAIV-induced immune responses and developing predictive models for vaccine immunogenicity, with applications in precision-guided vaccination strategies.","type":"string"},"datatype":"string"},"type":"statement","id":"Q6694831$464D06CC-F864-45C9-B2A1-0130525EE7B0","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"221cf285fb8d824dec01424ed366bb4ae0ccf59b","datavalue":{"value":{"time":"+2025-01-22T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q6694831$0FBCD2F6-19CE-4316-91C4-061089D77182","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"2368b525cced127017dbb4fa649c36b5e1f23425","datavalue":{"value":{"entity-type":"item","numeric-id":146452,"id":"Q146452"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6694831$2C361E35-4234-4941-8D4A-EEB8DB1D32EF","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"f681e457d6a53e9bb1bc93a78b7b6304f836a347","datavalue":{"value":{"entity-type":"item","numeric-id":146448,"id":"Q146448"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6694831$F07031C3-37E9-4946-A5F4-ED5EA0F54923","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P16","hash":"44a1a1bc474b4539be23805cf51e60c6f2fa1678","datavalue":{"value":{"entity-type":"item","numeric-id":6694830,"id":"Q6694830"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6694831$71F0BCCD-FE3A-4C71-978B-90D8CF3D6BBB","rank":"normal"}],"P227":[{"mainsnak":{"snaktype":"value","property":"P227","hash":"38ab05f596de95b42dc75c029209be7afddc8d88","datavalue":{"value":"14719593","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q6694831$995BCAEE-60D3-4494-B483-CCDDE8D8B14D","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"b3019db6d66700bb071977b64997c5ebcff73a76","datavalue":{"value":"10.5281/zenodo.14719593","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q6694831$3C01FDE6-B038-4D95-913A-A19DE32D407C","rank":"normal"}],"P163":[{"mainsnak":{"snaktype":"value","property":"P163","hash":"45fcd4163b5f33e6e8c784f5522d7246c0a1a61e","datavalue":{"value":{"entity-type":"item","numeric-id":57056,"id":"Q57056"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6694831$5FBCE587-97C9-47BE-8BE9-9895582D930F","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"d1e8073b72a070520efd3d14d4b3d2d3d03859e2","datavalue":{"value":{"entity-type":"item","numeric-id":5984635,"id":"Q5984635"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6694831$8453D5F3-2A79-4467-A8C2-FE4EA78076EF","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"Comprehensive Multimodal Immune Response Dataset for LAIV Vaccination in Pediatric Cohorts","badges":[],"url":"https://portal.mardi4nfdi.de/wiki/Comprehensive_Multimodal_Immune_Response_Dataset_for_LAIV_Vaccination_in_Pediatric_Cohorts"}}}}}