{"entities":{"Q6702807":{"pageid":14421779,"ns":120,"title":"Item:Q6702807","lastrevid":54701402,"modified":"2026-01-29T19:56:49Z","type":"item","id":"Q6702807","labels":{"en":{"language":"en","value":"Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study"}},"descriptions":{"en":{"language":"en","value":"Dataset published at Zenodo repository."}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"dae155fd0809a7906855cd4fa50dd7d71bed552b","datavalue":{"value":{"entity-type":"item","numeric-id":56885,"id":"Q56885"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q6702807$0943A2AA-3D10-4EF9-8013-8CBAB16FC717","rank":"normal"}],"P1459":[{"mainsnak":{"snaktype":"value","property":"P1459","hash":"deb225891d57389bb1886c38f243c06df6e93870","datavalue":{"value":"Dataset for:https://www.frontiersin.org/articles/10.3389/fmed.2023.1227786/abstract    Predictive risk factors before the onset of familial rheumatoid arthritis: the Tatarstan cohort study    Background: A familial history of rheumatoid arthritis (RA) predisposes an individual for developing RA. This study aimed at investigating factors associated with this conversion from the Tatarstan cohort.Methods: 144 individuals, referred to as pre-RA and at risk for familial RA, were selected 2 years (range: 2 to 21 years) before conversion to RA and compared to non-converted 328 first degree relatives (FDR) from RA as assessed after  2 years follow-up, and 355 healthy controls (HC). Preclinical parameters, and socio-demographic/individual/HLA genetic factors were analyzed when data were available at the time of enrolment.Results: As compared to FDR and HC groups, pre-RA individuals were characterized before conversion to RA by the presence of arthralgia, severe morning symptoms, a lower educational level, and rural location. An association with the HLA-DRB1 SE risk factor was also retrieved with symmetrical arthralgia and passive smoking. On the contrary, alcohol consumption and childless in women were protective and associated with the HLA-DRB1*07:01 locus.Conclusion: Before RA onset, a combination of individual and genetic factors characterized those who are at risk of progressing to RA among those with familial RA 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