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As this may happen anywhere, naive T\u00a0cells ought to visit all lymph\u00a0nodes. Here, deep sequencing almost-complete TCR-repertoires led to a comparison of different lymph\u00a0nodes within and between individual mice. We find strong evidence for a deterministic CD4/CD8 lineage choice and a consistent spatial structure. Specifically, some T\u00a0cells show a preference for one or multiple lymph\u00a0nodes, suggesting that their TCR interacts with locally presented (self-)peptides. These findings are mirrored in TCR-transgenic mice showing localized CD69-expression, retention, and cell division. 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