{"entities":{"Q725696":{"pageid":727545,"ns":120,"title":"Item:Q725696","lastrevid":63862911,"modified":"2026-04-11T16:03:26Z","type":"item","id":"Q725696","labels":{"en":{"language":"en","value":"Incoherent dose-escalation in phase I trials using the escalation with overdose control approach"}},"descriptions":{"en":{"language":"en","value":"scientific article; zbMATH DE number 6912435"}},"aliases":{},"claims":{"P31":[{"mainsnak":{"snaktype":"value","property":"P31","hash":"fd5912e4dab4b881a8eb0eb27e7893fef55176ad","datavalue":{"value":{"entity-type":"item","numeric-id":56887,"id":"Q56887"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$4393E71F-AA10-4046-A45A-3B292B188B9E","rank":"normal"}],"P159":[{"mainsnak":{"snaktype":"value","property":"P159","hash":"a5a1ba3cd41cbca66a3809b4069265ffc4d323f7","datavalue":{"value":{"text":"Incoherent dose-escalation in phase I trials using the escalation with overdose control approach","language":"en"},"type":"monolingualtext"},"datatype":"monolingualtext"},"type":"statement","id":"Q725696$FD19034D-1484-4103-9047-2FC235E1D0AB","rank":"normal"}],"P225":[{"mainsnak":{"snaktype":"value","property":"P225","hash":"4727ea160dedbaae1a48f38f6a1ab09327c94fe8","datavalue":{"value":"1398.62351","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q725696$B4D7FF5A-D4F2-460E-85A7-7AD6409176FE","rank":"normal"}],"P16":[{"mainsnak":{"snaktype":"value","property":"P16","hash":"c6ab477678f6c3af0c2ebda5c1a37f4bb45e84b2","datavalue":{"value":{"entity-type":"item","numeric-id":725695,"id":"Q725695"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$4F9D2FEE-633C-441D-9064-DA8205881366","rank":"normal"}],"P200":[{"mainsnak":{"snaktype":"value","property":"P200","hash":"c04c0aa73445114ccad8ca80f237696c280ad285","datavalue":{"value":{"entity-type":"item","numeric-id":64295,"id":"Q64295"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$001B800B-AF0E-49EC-A9CE-78581C61EA9B","rank":"normal"}],"P28":[{"mainsnak":{"snaktype":"value","property":"P28","hash":"a9aa22cb8a96ecb8781adebec8cb26e1601a98e8","datavalue":{"value":{"time":"+2018-08-02T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q725696$10368F09-2BFF-481B-B428-C8DFCFFFFEAD","rank":"normal"}],"P1448":[{"mainsnak":{"snaktype":"value","property":"P1448","hash":"288779d5b23c006e1129e25c14983e94512a028c","datavalue":{"value":"A desirable property of any dose-escalation strategy for phase I oncology trials is coherence: if the previous patient experienced a toxicity, a higher dose is not recommended for the next patient; similarly, if the previous patient did not experience a toxicity, a lower dose is not recommended for the next patient. This paper formalizes a proof that incoherent dose-escalation can occur if the feasibility bound is increased without consideration of preceding toxicity outcomes, and shows via simulation studies that only small increases in the feasibility bound are required for incoherent dose-escalations to occur.","type":"string"},"datatype":"string"},"type":"statement","id":"Q725696$AE68AE2E-D9C6-4371-A7AC-EC1F0AE4B7BD","rank":"normal"}],"P1447":[{"mainsnak":{"snaktype":"value","property":"P1447","hash":"a4acbd42b7192fc4dfc7a11c35abd52ea863d593","datavalue":{"value":{"entity-type":"item","numeric-id":590903,"id":"Q590903"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$965A8D0A-05E0-41DD-8777-521F3A3F7B48","rank":"normal"}],"P226":[{"mainsnak":{"snaktype":"value","property":"P226","hash":"708a6f1a75f978962215fcdf6748c16c77f4fd6e","datavalue":{"value":"62P10","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q725696$4660C635-2D70-456C-A3B4-DBCFB0857129","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"2c0c09d2caba66ba44b1be99e80b2f2867b9bbb8","datavalue":{"value":"62L05","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q725696$425C6151-A459-4B68-892A-E519C79C00BF","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"2474c99ceba943e04dda4ddfffedfe45f5fdfd62","datavalue":{"value":"62F15","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q725696$FA19D164-4EAB-45BC-AA89-588961EE69F2","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P226","hash":"e27beffea4779e8a96e7c5961e8cc7879483d808","datavalue":{"value":"92C50","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q725696$9BF552CA-7F48-4AD4-9C3B-A5BF139E82FF","rank":"normal"}],"P1451":[{"mainsnak":{"snaktype":"value","property":"P1451","hash":"94f5470c460fe16a3c61efbea095f9eea309d26a","datavalue":{"value":"6912435","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q725696$81EE3E82-5312-4D61-BAC9-681E71767365","rank":"normal"}],"P1450":[{"mainsnak":{"snaktype":"value","property":"P1450","hash":"bca0f285113f3d767ef04a29bc67506a8ca3dc42","datavalue":{"value":"Bayesian statistics","type":"string"},"datatype":"string"},"type":"statement","id":"Q725696$403132EB-18A1-4909-989D-9CCF5836D3C7","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"6e5973c0c18bc378ac925872383d3eaa5eb79bdd","datavalue":{"value":"dose-escalation","type":"string"},"datatype":"string"},"type":"statement","id":"Q725696$A691F04D-C772-4AF0-9DD3-1A331F678EF1","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"9409c4a85a96a58f224e4e8d924ae95f4615cf71","datavalue":{"value":"adaptive designs","type":"string"},"datatype":"string"},"type":"statement","id":"Q725696$94758198-28AA-4394-9123-63E1D5FF16E0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"b50169ec01f6845be46058e4f2d528ac1c94587c","datavalue":{"value":"maximum tolerated dose","type":"string"},"datatype":"string"},"type":"statement","id":"Q725696$D3575749-5B54-4EFC-A592-D2D28636977E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"ba818d292861321658b3d3370054dd6fa7a370e6","datavalue":{"value":"phase I trials","type":"string"},"datatype":"string"},"type":"statement","id":"Q725696$4CDA7D7F-9693-4D11-BA90-778383CE7FE0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1450","hash":"9490545d864dc4d4d3b5053469ec7bc8ef0582a9","datavalue":{"value":"coherence","type":"string"},"datatype":"string"},"type":"statement","id":"Q725696$6788B045-0E0E-4820-B01A-F34CD84EF249","rank":"normal"}],"P1463":[{"mainsnak":{"snaktype":"value","property":"P1463","hash":"de54fb4593154e641771033ca3ce307d64416db6","datavalue":{"value":{"entity-type":"item","numeric-id":39522,"id":"Q39522"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$07728CF4-8192-43FC-A9EC-77C67D4C0E95","rank":"normal"}],"P1460":[{"mainsnak":{"snaktype":"value","property":"P1460","hash":"57f7fea50d2ce1b39b695c4a1313582eed405e38","datavalue":{"value":{"entity-type":"item","numeric-id":5976449,"id":"Q5976449"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$16AC733C-56DA-41D1-BD6A-6DE6096FE2EC","rank":"normal"}],"P205":[{"mainsnak":{"snaktype":"value","property":"P205","hash":"55536ba84d4c5a76fb029acc38d430b5cada17d2","datavalue":{"value":"https://doi.org/10.1007/s00362-016-0790-7","type":"string"},"datatype":"url"},"type":"statement","id":"Q725696$A9FFC3BC-ED80-45D6-A27D-48511D25654C","rank":"normal"}],"P388":[{"mainsnak":{"snaktype":"value","property":"P388","hash":"87f6e50eb2b95fea70f120e575cf20f32656f1b1","datavalue":{"value":"W2467367917","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q725696$A9D49B19-85EF-4A9D-A629-C03A11C3C083","rank":"normal"}],"P12":[{"mainsnak":{"snaktype":"value","property":"P12","hash":"0baf27f76be5949a47aa96feb896ff1a20b4b164","datavalue":{"value":"Q54987395","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q725696$C5B85362-621D-4E70-8A1C-D81511AB98AA","rank":"normal"}],"P223":[{"mainsnak":{"snaktype":"value","property":"P223","hash":"05325479e3b8cf435dddbe985b0c39c9bddd2090","datavalue":{"value":{"entity-type":"item","numeric-id":1265963,"id":"Q1265963"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$92B680D6-F907-4834-B0B9-69B085952AC8","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"34e7ee25d5c46e6e1f34b32a7775ef43814dbcfd","datavalue":{"value":{"entity-type":"item","numeric-id":3013989,"id":"Q3013989"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$7B841156-4F4E-4445-9ED2-C70E2928C9C3","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"c9cc64da575b4f330443da1e1bed056d74f0571c","datavalue":{"value":{"entity-type":"item","numeric-id":3545408,"id":"Q3545408"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$1E586C13-6F24-47D9-B8AE-95F9AC414E2E","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"80dcf153e75bc2359c7c388ed4f2afc56058ddc0","datavalue":{"value":{"entity-type":"item","numeric-id":903293,"id":"Q903293"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$225F5D63-3799-43FF-99C5-7C830060B7CD","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"f896bdfc956808932590ed383c77c699929ab6e7","datavalue":{"value":{"entity-type":"item","numeric-id":4670477,"id":"Q4670477"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$F6DDDFFE-068A-4C65-9D52-6CA857B11AD0","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"a611b04cf2be93ab69974711649c6b49cbc2c7cb","datavalue":{"value":{"entity-type":"item","numeric-id":1007501,"id":"Q1007501"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$AA39EE01-BEAE-480E-87D0-BAFA71BDE366","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"48c8542dbd999e2b8d1b6ee5fd598dbe0578e3db","datavalue":{"value":{"entity-type":"item","numeric-id":345352,"id":"Q345352"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$666BE6C8-500A-437E-B759-F5FBE0456AFF","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"55d6d3a478261988857f5116b12213a08fb21fa2","datavalue":{"value":{"entity-type":"item","numeric-id":434398,"id":"Q434398"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$5F9F6E10-9A16-4147-A286-3258B6F8C5AF","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"18323a49171b0bee5278e7b269e947eb64acbb09","datavalue":{"value":{"entity-type":"item","numeric-id":70258,"id":"Q70258"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$CE49E9E8-B942-46CE-A674-F696E2E440C2","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"abef7bfcb29a20db8de43b2b24baa3139b3c78c0","datavalue":{"value":{"entity-type":"item","numeric-id":1961766,"id":"Q1961766"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$78795301-3403-437C-8CBD-4AEE2CE16D4A","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P223","hash":"dbf3f87d9e1ce630a00b72479fb46ab39fa3f0ad","datavalue":{"value":{"entity-type":"item","numeric-id":3201544,"id":"Q3201544"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$D7441451-A24A-4C51-85BA-4B98FF784D1B","rank":"normal"}],"P27":[{"mainsnak":{"snaktype":"value","property":"P27","hash":"c5de69aacb1e6c267b176f60046d6872c12d0f8b","datavalue":{"value":"10.1007/S00362-016-0790-7","type":"string"},"datatype":"external-id"},"type":"statement","id":"Q725696$036C8EE1-F806-447D-B750-5D5058EFF1FA","rank":"normal"}],"P1643":[{"mainsnak":{"snaktype":"value","property":"P1643","hash":"f1b12880aa8ea3b740c45f6810657b30acb682f5","datavalue":{"value":{"entity-type":"item","numeric-id":3545408,"id":"Q3545408"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"89bfa375ddae259b754e06f06a4db4ef2e3679a3","datavalue":{"value":{"amount":"+0.8292890787124634","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q725696$93A908E2-3779-4D60-A9DA-36811E5C1F6B","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"f8bd1104386881eb31605abd0582a5752dd7386c","datavalue":{"value":{"entity-type":"item","numeric-id":1929691,"id":"Q1929691"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"032c9ee1dce7d550682603dbc256e7180551f5ce","datavalue":{"value":{"amount":"+0.7629486918449402","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q725696$7586E4CF-2339-4BF3-947E-C749423275EC","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"b8c358a674e214e7fb94a96d4ffb2daf23bb91b7","datavalue":{"value":{"entity-type":"item","numeric-id":1265963,"id":"Q1265963"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"22878fea1194362ea3b8b8e5ebbebb3e9cf7b753","datavalue":{"value":{"amount":"+0.7614433169364929","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q725696$07357EDB-775C-40EB-A035-C5DA95B225B2","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"d733e2218688d9733a9cab66002907ce17aea585","datavalue":{"value":{"entity-type":"item","numeric-id":1929695,"id":"Q1929695"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"59babf7a54b70e909221f2c336e4b4bba9ab3b08","datavalue":{"value":{"amount":"+0.7358168959617615","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q725696$1FF496E4-7171-48AC-86F5-65A84557FE5D","rank":"normal"},{"mainsnak":{"snaktype":"value","property":"P1643","hash":"c5137c747be8bdec7cae950ca08a2dc23784111b","datavalue":{"value":{"entity-type":"item","numeric-id":903293,"id":"Q903293"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","qualifiers":{"P1659":[{"snaktype":"value","property":"P1659","hash":"669ff6a49047b750805befd25446a372ae1adbe2","datavalue":{"value":{"amount":"+0.7306364178657532","unit":"1"},"type":"quantity"},"datatype":"quantity"}],"P1660":[{"snaktype":"value","property":"P1660","hash":"a327a09ea0305e98d5cf33bd4036320e19f2aed0","datavalue":{"value":{"entity-type":"item","numeric-id":6821328,"id":"Q6821328"},"type":"wikibase-entityid"},"datatype":"wikibase-item"}]},"qualifiers-order":["P1659","P1660"],"id":"Q725696$440A8E05-CDAD-48D2-A135-3BE221D366BB","rank":"normal"}],"P163":[{"mainsnak":{"snaktype":"value","property":"P163","hash":"45fcd4163b5f33e6e8c784f5522d7246c0a1a61e","datavalue":{"value":{"entity-type":"item","numeric-id":57056,"id":"Q57056"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q725696$AD5D8AFF-2401-40A0-85EB-819615AFFF03","rank":"normal"}]},"sitelinks":{"mardi":{"site":"mardi","title":"Incoherent dose-escalation in phase I trials using the escalation with overdose control approach","badges":[]}}}}}