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As a result, many statistical methods have been developed to  identify genetic variants that are involved in epistasis, and nearly all of  these approaches carry out this task by focusing on analyzing one trait at a  time. Previous studies have shown that jointly modeling multiple phenotypes  can often dramatically increase statistical power for association mapping. In  this  package, we present the 'multivariate MArginal ePIstasis Test'  ('mvMAPIT') \u2013 a multi-outcome generalization of a recently proposed epistatic  detection method which seeks to detect marginal epistasis or the combined  pairwise interaction effects between a given variant and all other variants.  By searching for marginal epistatic effects, one can identify genetic variants  that are involved in epistasis without the need to identify the exact  partners with which the variants interact \u2013 thus, potentially alleviating  much of the statistical and computational burden associated with conventional  explicit search based methods. Our proposed 'mvMAPIT' builds upon this  strategy by taking advantage of correlation structure between traits to  improve the identification of variants involved in epistasis.  We formulate 'mvMAPIT' as a  multivariate linear mixed model and develop a  multi-trait variance component estimation algorithm for efficient parameter  inference and P-value computation. Together with reasonable model  approximations, our proposed approach is scalable to moderately sized  genome-wide association studies.  Crawford et al. (2017) <doi:10.1371/journal.pgen.1006869>.  Stamp et al. 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