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By Theorem 5.5 of \\textit{M. Hochster} and \\textit{C. Huneke} [Ann. Math. (2) 135, No. 1, 53--89 (1992; Zbl 0753.13003)] \\(R^+\\) is a balanced big Cohen-Macaulay algebra in the case \\(R\\) is an excellent local domain of prime characteristic, i.e., every system of parameters in R is a regular sequence on \\(R^+\\). But if \\(R\\) is of characteristic zero and of dimension \\(\\geq4\\), \\(R^+\\) is not balanced big Cohen-Macaulay algebra [see Proposition 3.6 of \\textit{I. M. Aberbach} and \\textit{M. Hochster}, J. Pure Appl. Algebra 122, No. 3, 171--184 (1997; Zbl 0908.13006)]. Now assume that \\((R,m, k)\\) is a local excellent domain of mixed characteristic \\(p\\) and of dimension \\(\\geq 3\\). Then the main result of the paper under review says that \\(H^1_m(R^+/\\sqrt{p R^+}) = 0\\) and every part of a system of parameters of \\(R/\\sqrt{p R}\\) of length two is a regular sequence on \\(R^+/\\sqrt{p 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