Task:6684594

Community: MathModDB

computational task

linear task

Available identifiers

MaRDI QIDQ6684594

linear fit to determine the limiting reaction rate, michaelis constant and inhibition constants, named after Malcolm Dixon

List of contained entities

Dixon equation (uni uni reaction without product and non-competitive complete inhibition - steady state assumption)	$\frac{1}{v_0}=\frac{1}{V_{max,f}}(1+\frac{K_m}{c_S})+\frac{c_I}{V_{max,f}}(\frac{1}{K_{iu}}+\frac{K_m}{K_{ic}*c_S})$
	$K_S$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{ic}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{iu}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{max,f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_I$ represents inhibitor concentration
	$c_S$ represents substrate concentration
	$v_0$ represents initial reaction rate
Michaelis constant substrate (uni uni reaction - steady state assumption)	$K_S\equiv \frac{k_{-1}+k_2}{k_1}$	output
	$k_{-1}$ represents reaction rate constant
	$k_1$ represents reaction rate constant
	$k_2$ represents reaction rate constant
	$K_S$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
competitive inhibition constant (uni uni reaction reversible inhibition)	$K_{ic}\equiv \frac{k_{-3}}{k_3}$	output
	$k_3$ represents reaction rate constant
	$k_{-3}$ represents reaction rate constant
	$K_{ic}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
inhibitor concentration
initial reaction rate
limiting reaction rate (uni uni reaction - forward)	$V_{max,f}\equiv k_2{c}_{E_0}$	output
	$c_{E_0}$ represents enzyme concentration
	$k_2$ represents reaction rate constant
	$V_{max,f}$ represents limiting reaction rate (uni uni reaction - forward)
substrate concentration
uncompetitive inhibition constant (uni uni reaction reversible inhibition)	$K_{iu}\equiv \frac{k_{-4}}{k_4}$	output
	$k_4$ represents reaction rate constant
	$k_{-4}$ represents reaction rate constant
	$K_{iu}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)

Further items linking to linear parameter estimation (uni uni reaction without product and non-competitive complete inhibition - Dixon model - steady state assumption)

Item	Property
linear parameter estimation of enzyme kinetics	specialized by
nonlinear parameter estimation (uni uni reaction without product and non-competitive complete inhibition - Michaelis Menten model - steady state assumption)	linearized by
uni uni reaction non-competitive complete inhibition (Dixon model without product - steady state assumption)	used by

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