Model:6775434

Community: MathModDB

mathematical model

Available identifiers

MaRDI QIDQ6775434

generalized compartment-based model for morphogen gradient modelling

Description

Assuming that molecules of species A diffuse significantly faster than those of species B, a larger compartment size for A is chosen.

List of contained entities

generalized Poisson distribution	$\varphi (𝐧,𝐦)=\exp [-\sum _{j=1}^{K_A}{\overline{A}}_j-\sum _{i=1}^{K_B}{\overline{B}}_i]\prod _{j=1}^{K_A}\frac{{\overline{A}}_j^{n_j}}{n_j!}\prod _{i=1}^{K_B}\frac{{\overline{B}}_i^{m_i}}{m_i!}$
	$\varphi$ represents stationary distribution
generalized compartment reaction	$A_j\stackrel{k_2/\gamma }{\to }{B}_i,j=1,2,\dots ,K_A$
	$A$ represents signal
	$B$ represents morphogen
	$\gamma$ represents compartment length ratio
generalized steady state equations	$\begin{array}{ccc}(\frac{D_A}{h_A^2}{S}_A-k_2{I}_A)\overline{𝐀}& =& -k_1{𝐞}_1\\ (\frac{D_B}{h_B^2}{S}_B-k_3{I}_B)\overline{𝐁}& =& -\frac{k_2}{\gamma }M\overline{𝐀}\end{array}$
	$D_A$ represents diffusion coefficient a
	$D_B$ represents diffusion coefficient b
	$S$ represents matrix S
	${\bar{A}}_i$ represents average number of molecules of signal
	${\bar{B}}_i$ represents average number of molecules of morphogen
	$M$ represents matrix M
multi grid reaction diffusion master equation	$\frac{\partial p}{\partial t}(𝐧,𝐦,t)=(\widetilde{𝒟}+\widetilde{ℛ})p(𝐧,𝐦,t)$
	$\widetilde{𝒟}$ represents generalized diffusion operator
	$\widetilde{ℛ}$ represents generalized reaction operator
	$p(\mathbb{(}n),\mathbb{(}m),t)$ represents joint probability
product of Poisson distributions from the mgRDME	$\varphi (𝐧,𝐦)=\exp [-\sum _{j=1}^{K_A}{\overline{A}}_j-\sum _{i=1}^{K_B}{\overline{B}}_i]\prod _{j=1}^{K_A}\frac{{\overline{A}}_j^{n_j}}{n_j!}\prod _{i=1}^{K_B}\frac{{\overline{B}}_i^{m_i}}{m_i!}$
	$\bar{A}$ represents average number of molecules of signal
	$\bar{B}$ represents average number of molecules of morphogen
	$\varphi (𝕟,𝕞)$ represents stationary distribution
stationary multi grid reaction diffusion master equation	$0=(\widetilde{𝒟}+\widetilde{ℛ})p(𝕟,𝕞,t)$
	$\widetilde{𝒟}$ represents generalized diffusion operator
	$\widetilde{ℛ}$ represents generalized reaction operator
	$p(𝕟,𝕞,t)$ represents joint probability
stationary reaction-diffusion master equation	$0=(𝒟+ℛ)\varphi (𝐧,𝐦)$
	$𝒟$ represents diffusion operator
	$ℛ$ represents reaction operator
	$\varphi$ represents stationary distribution

List of assumptions

a produced in first compartment

reaction diffusion system

Described at:

Multi-grid reaction-diffusion master equation: applications to morphogen gradient modelling

This page was built for model: generalized compartment based morphogen gradient model