DRviaSPCN (Q113676): Difference between revisions

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@@ Property / last update @@
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+A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.
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+Junwei Han
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+Jiashuo Wu
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+GNU General Public License, version 2.0
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+GNU General Public License, version 3.0
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Revision as of 14:56, 27 February 2024

Drug Repurposing in Cancer via a Subpathway Crosstalk Network

Language	Label	Description	Also known as
English	DRviaSPCN	Drug Repurposing in Cancer via a Subpathway Crosstalk Network

Statements

instance of

R package

0 references

software version identifier

0.1.2

publication date

3 March 2022

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0.1.0

publication date

9 December 2021

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0.1.1

publication date

28 February 2022

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0.1.3

publication date

25 September 2023

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0.1.4

publication date

13 January 2024

0 references

0 references

0 references

13 January 2024

0 references

description

A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.

0 references

0 references

0 references

GNU General Public License, version 2.0

0 references

GNU General Public License, version 3.0

edition/version

expanded from: GPL (≥ 2) (English)