Greedy adaptive walks on a correlated fitness landscape

DOI10.1016/J.JTBI.2016.02.035zbMATH Open1343.92366arXiv1507.03511OpenAlexW2198000277WikidataQ50697020 ScholiaQ50697020MaRDI QIDQ306863FDOQ306863

Joachim Krug, Su-Chan Park, Johannes Neidhart

Publication date: 1 September 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: We study adaptation of a haploid asexual population on a fitness landscape defined over binary genotype sequences of length $L$. We consider greedy adaptive walks in which the population moves to the fittest among all single mutant neighbors of the current genotype until a local fitness maximum is reached. The landscape is of the rough mount Fuji type, which means that the fitness value assigned to a sequence is the sum of a random and a deterministic component. The random components are independent and identically distributed random variables, and the deterministic component varies linearly with the distance to a reference sequence. The deterministic fitness gradient $c$ is a parameter that interpolates between the limits of an uncorrelated random landscape ($c=0$) and an effectively additive landscape ($coinfty$). When the random fitness component is chosen from the Gumbel distribution, explicit expressions for the distribution of the number of steps taken by the greedy walk are obtained, and it is shown that the walk length varies non-monotonically with the strength of the fitness gradient when the starting point is sufficiently close to the reference sequence. Asymptotic results for general distributions of the random fitness component are obtained using extreme value theory, and it is found that the walk length attains a non-trivial limit for $Loinfty$, different from its values for $c=0$ and $c=infty$, if $c$ is scaled with $L$ in an appropriate combination.

Full work available at URL: https://arxiv.org/abs/1507.03511

zbMATH Keywords

adaptationextreme value theoryasexual populationgenotype space

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Cites Work

• Title not available (Why is that?)
• Hypergeometric Orthogonal Polynomials and Their q-Analogues
• A simple stochastic gene substitution model
• On the existence of accessible paths in various models of fitness landscapes
• A simple model for the balance between selection and mutation
• A minimum on the mean number of steps taken in adaptive walks
• A sharp minimum on the mean number of steps taken in adaptive walks
• Exact results for amplitude spectra of fitness landscapes
• Some non-standard problems in viscous flow
• Records and sequences of records from random variables with a linear trend
• Quantitative analyses of empirical fitness landscapes
• Analysis of adaptive walks on NK fitness landscapes with different interaction schemes
• Protein evolution on partially correlated landscapes.
• The speed of evolution in large asexual populations

Cited In (4)

• From adaptive dynamics to adaptive walks
• Adaptive walks on high-dimensional fitness landscapes and seascapes with distance-dependent statistics
• Universality classes of interaction structures for NK fitness landscapes
• Record statistics for random walks and Lévy flights with resetting

This page was built for publication: Greedy adaptive walks on a correlated fitness landscape

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q306863)