On the relationship between sloppiness and identifiability

DOI10.1016/J.MBS.2016.10.009zbMath1352.92059OpenAlexW2538433428WikidataQ39241976 ScholiaQ39241976MaRDI QIDQ343083

Eva Balsa-Canto, Oana-Teodora Chis, Julio R. Banga, Alejandro Fernández Villaverde

Publication date: 21 November 2016

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: http://hdl.handle.net/10261/139453

zbMATH Keywords

parameter estimationidentifiabilityoptimal experimental designsloppiness

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Related Items (10)

Practical identifiability of parametrised models: a review of benefits and limitations of various approaches ⋮ Hierarchically goal-oriented prediction of skeletal muscle tissue constitutive behavior considering histological characteristics ⋮ Observability and structural identifiability of nonlinear biological systems ⋮ Parameter redundancy and identifiability in hidden Markov models ⋮ Frequency domain identifiability and sloppiness of descriptor systems with an LFT structure ⋮ Making predictions using poorly identified mathematical models ⋮ On near-redundancy and identifiability of parametric hazard regression models under censoring ⋮ Global sensitivity analysis for the design of nonlinear identification experiments ⋮ Optimal experimental design for linear time invariant state-space models ⋮ A computational approach to the structural analysis of uncertain kinetic systems

Uses Software

• GenSSI
• AMIGO

Cites Work

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• Identification of parametric models from experimental data. Transl. from an upd. French version by the authors, with the help of John Norton
• Numerical parameter identifiability and estimability: Integrating identifiability, estimability, and optimal sampling design
• System identifiability based on the power series expansion of the solution
• Complexity reduction preserving dynamical behavior of biochemical networks
• Parameter uncertainty in biochemical models described by ordinary differential equations
• On Identifiability of Nonlinear ODE Models and Applications in Viral Dynamics
• Principal component analysis in linear systems: Controllability, observability, and model reduction

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