Detecting simultaneous variant intervals in aligned sequences

DOI10.1214/10-AOAS400zbMath1223.62166arXiv1108.3177MaRDI QIDQ641121

Nancy R. Zhang, Benjamin Yakir, David O. Siegmund

Publication date: 21 October 2011

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1108.3177

zbMATH Keywords

segmentation; scan statistics; change-point detection; DNA copy number

Mathematics Subject Classification ID

62P10: Applications of statistics to biology and medical sciences; meta analysis

92C40: Biochemistry, molecular biology

Related Items

Author's Response, Change-Points: From Sequential Detection to Biology and Back, Discussion on “Change-Points: From Sequential Detection to Biology and Back” by David Siegmund, Exact tests for offline changepoint detection in multichannel binary and count data with application to networks, A combined SR-CUSUM procedure for detecting common changes in panel data, Asymptotic distribution-free change-point detection based on interpoint distances for high-dimensional data, Collective Anomaly Detection in High-Dimensional Var Models, Sequential multi-sensor change-point detection, Scan statistics for detecting a local change in variance for normal data with known variance, Scan statistics on Poisson random fields with applications in genomics, Change-point model on nonhomogeneous Poisson processes with application in copy number profiling by next-generation DNA sequencing, Optimal detection of multi-sample aligned sparse signals, Multi-sensor slope change detection, Sequential tests controlling generalized familywise error rates, A novel change-point approach for the detection of gas emission sources using remotely contained concentration data, On extremal index of max-stable random fields, Online multivariate changepoint detection with type I error control and constant time/memory updates per series, Testing randomness online, BayesProject: fast computation of a projection direction for multivariate changepoint detection, Graph-based change-point detection, Higher criticism: \(p\)-values and criticism, Sequential model selection-based segmentation to detect DNA copy number variation, Multiple Testing with the Structure-Adaptive Benjamini–Hochberg Algorithm

Uses Software

• PennCNV

Cites Work

• The statistics of gene mapping
• A new representation for a renewal-theoretic constant appearing in asymptotic approximations of large deviations
• Tail probabilities for the null distribution of scanning statistics
• Self-organization and the dynamical nature of ventricular fibrillation
• Detecting simultaneous changepoints in multiple sequences
• Tail Approximations for Maxima of Random Fields by Likelihood Ratio Transformations
• Circular binary segmentation for the analysis of array-based DNA copy number data
• A Modified Bayes Information Criterion with Applications to the Analysis of Comparative Genomic Hybridization Data
• Error Distribution for Gene Expression Data