A diffusion process with killing: The time to formation of recurrent deleterious mutant genes

DOI10.1016/0304-4149(82)90012-6zbMath0487.92011OpenAlexW2044581958MaRDI QIDQ1165791

Samuel Karlin, Simon Tavaré

Publication date: 1982

Published in: Stochastic Processes and their Applications (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0304-4149(82)90012-6

zbMATH Keywords

finite populationdiffusion approximationsMarkov chain modelsgenotypesformation of recurrent deleterious mutant genesinfinitesimal driftkilling timesstate-dependent killing rate

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Genetics and epigenetics (92D10) Continuous-time Markov processes on discrete state spaces (60J27) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70)

Related Items

Conditioning diffusion processes with killing rates, Conditioning diffusion processes with respect to the local time at the origin, Associated Stieltjes-Carlitz polynomials and a generalization of Heun's differential equation, Joint distribution of two local times for diffusion processes with the application to the construction of various conditioned processes, A diffusion approach to approximating preservation probabilities for gene duplicates, Waiting with and without recombination: The time to production of a double mutant, Some results on co-recursive associated Meixner and Charlier polynomials

Cites Work

• The detection of particular genotypes in finite populations I. Natural selection effects
• The detection of particular genotypes in finite populations II. The effects of partial penetrance and family structure
• On the past history of an allele now known to have frequencyp
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