Alternative designs for a genetic switch: Analysis of switching times using the piecewise power-law representation

DOI10.1016/S0025-5564(02)00113-XzbMath1020.92022WikidataQ44185119 ScholiaQ44185119MaRDI QIDQ1867122

Michael A. Savageau

Publication date: 2 April 2003

Published in: Mathematical Biosciences (Search for Journal in Brave)

zbMATH Keywords

thresholdsrobustnessordinary differential equationsdesign principlescircuit connectivitydiscontinuous vs. continuous switchingswitching effort

Mathematics Subject Classification ID

Problems related to evolution (92D15) Genetics and epigenetics (92D10)

Related Items (11)

Robust \(H_\infty\) control of discrete switched system with time delay ⋮ Biochemical systems theory: a review ⋮ The asymptotical behavior of cyclic genetic regulatory networks ⋮ Requirement for multiple activation signals by anti-inflammatory feedback in macrophages ⋮ Piecewise synergetic systems and applications in biochemical systems theory ⋮ Multistability of genetic regulatory networks ⋮ Design of the lac gene circuit revisited ⋮ Bistable responses in bacterial genetic networks: designs and dynamical consequences ⋮ The timing of TNF and IFN-\(\gamma\) signaling affects macrophage activation strategies during \textit{Mycobacterium tuberculosis} infection ⋮ To switch or taper off: the dynamics of saturation ⋮ Controllability of non-linear biochemical systems

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• Synergism analysis of biochemical systems. I: Conceptual framework
• Synergism analysis of biochemical systems. II: Tensor formulation and treatment of stoichiometric constraints
• Design principles for elementary gene circuits: Elements, methods, and examples

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