Chemotherapy for tumors: An analysis of the dynamics and a study of quadratic and linear optimal controls

DOI10.1016/J.MBS.2006.05.003zbMath1122.49020OpenAlexW1980631767WikidataQ51922108 ScholiaQ51922108MaRDI QIDQ2455569

Yanyan Li

Publication date: 25 October 2007

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2006.05.003

zbMATH Keywords

singularchemotherapybang-bang controls

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Medical applications (general) (92C50) Existence of optimal solutions belonging to restricted classes (Lipschitz controls, bang-bang controls, etc.) (49J30) Optimality conditions for problems involving ordinary differential equations (49K15)

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Uses Software

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• MISER3
• XPPAUT

Cites Work

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• Thermodynamical analysis of the dynamics of tumor interaction with the host immune system
• Immunotherapy: an optimal control theory approach
• Modeling immunotherapy of the tumor -- immune interaction
• Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
• Optimal control applied to immunotherapy
• Mathematical modelling of the competition between tumors and immune system considering the role of the antibodies
• The dynamics of an optimally controlled tumor model: A case study
• Modelling and mathematical problems related to tumor evolution and its interaction with the immune system
• Optimal control for a stochastic model of cancer chemotherapy
• Analysis of a mathematical model for the growth of tumors under the action of external inhibitors
• Application of optimal control theory to analysis of cancer chemotherapy regimens
• Critical analysis and perspectives on kinetic (cellular) theory of immune competition
• Some optimal control problems in cancer chemotherapy with a toxicity limit
• Differential equations. Classical to controlled
• Cells behaving badly: A theoretical model for the fas/FasL system in tumour immunology
• Behavior of tumors under nonstationary therapy
• A mathematical model of cancer treatment by immunotherapy
• Mixed immunotherapy and chemotherapy of tumors: modeling, applications and biological interpretations
• Drug resistance in cancer chemotherapy as an optimal control problem
• A general framework for modeling tumor-immune system competition and immunotherapy: Mathematical analysis and biomedical inferences
• A Mathematical Tumor Model with Immune Resistance and Drug Therapy: An Optimal Control Approach
• QUALITATIVE ANALYSIS OF A MEAN FIELD MODEL OF TUMOR-IMMUNE SYSTEM COMPETITION
• Simulating, Analyzing, and Animating Dynamical Systems
• The High Order Maximal Principle and Its Application to Singular Extremals
• Toward Cultural Oncology: The Evolutionary Information Dynamics of Cancer
• Optimal Control Applied to Competing Chemotherapeutic Cell-Kill Strategies
• Comparison of optimal controls for a model in cancer chemotherapy withL₁- andL₂-type objectives
• ANALYSIS OF A NEW MODEL FOR TUMOR-IMMUNE SYSTEM COMPETITION INCLUDING LONG-TIME SCALE EFFECTS
• MATHEMATICAL TOPICS ON THE MODELLING COMPLEX MULTICELLULAR SYSTEMS AND TUMOR IMMUNE CELLS COMPETITION
• MODELLING OF THE IMMUNE RESPONSE: CONCEPTUAL FRAMEWORKS AND APPLICATIONS
• MATHEMATICAL MODELLING OF MACROPHAGE DYNAMICS IN TUMOURS
• Optimal Control Applied to Cell-Cycle-Specific Cancer Chemotherapy
• Optimal control of innate immune response
• Modeling tumor regrowth and immunotherapy

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