Multiscale Modeling of Follicular Ovulation as a Reachability Problem
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Publication:3523809
DOI10.1137/060664495zbMath1149.35388arXivq-bio/0607030OpenAlexW3105941137MaRDI QIDQ3523809
Nki Echenim, Michel Sorine, Frédérique Clément
Publication date: 5 September 2008
Published in: Multiscale Modeling & Simulation (Search for Journal in Brave)
Abstract: During each ovarian cycle, only a definite number of follicles ovulate, while the others undergo a degeneration process called atresia. We have designed a multi-scale mathematical model where ovulation and atresia result from a hormonal controlled selection process. A 2D-conservation law describes the age and maturity structuration of the follicular cell population. In this paper, we focus on the operating mode of the control, through the study of the characteristics of the conservation law. We describe in particular the set of microscopic initial conditions leading to the macroscopic phenomenon of either ovulation or atresia, in the framework of backwards reachable sets theory.
Full work available at URL: https://arxiv.org/abs/q-bio/0607030
Hyperbolic conservation laws (35L65) Physiology (general) (92C30) Cell biology (92C37) Geometric theory, characteristics, transformations in context of PDEs (35A30) Attainable sets, reachability (93B03) General biology and biomathematics (92B05)
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