Estimating Michaelis-Menten Parameters: Bias, Variance and Experimental Design

DOI10.2307/2529871zbMath0502.62096OpenAlexW2318499882MaRDI QIDQ3968360

David Currie

Publication date: 1982

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.2307/2529871

zbMATH Keywords

variancemaximum likelihoodbiasenzyme kineticsminimum variance unbiased estimatesestimating Michaelis-Menten parameters

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05) Design of statistical experiments (62K99) General nonlinear regression (62J02)

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The asymptotic properties of the Cornish-Bowden-Eisenthal median estimator ⋮ Estimation of the Michaelis-Menten parameters for reductive dechlorination of chlorinated solvents ⋮ Inference for nonconjugate Bayesian Models using the Gibbs sampler ⋮ Nonlinear regression modelling: a primer with applications and caveats ⋮ Fitting the Michaelis-Menten model ⋮ Corrected confidence intervals for adaptive nonlinear regression models ⋮ Optimal two-point designs for the michaelis-menten model with heteroscedastic errors ⋮ Optimal Designs When the Variance Is A Function of the Mean ⋮ Robust inference for nonlinear regression models ⋮ Two-stage estimation and simultaneous confidence band in partially nonlinear additive model

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