SIMULATING INDIVIDUAL-BASED MODELS OF BACTERIAL CHEMOTAXIS WITH ASYMPTOTIC VARIANCE REDUCTION

DOI10.1142/S0218202513500292zbMath1291.35417arXiv1111.5321OpenAlexW2085303242MaRDI QIDQ5411811

Giovanni Samaey, Mathias Rousset

Publication date: 25 April 2014

Published in: Unnamed Author (Search for Journal in Brave)

Abstract: We discuss variance reduced simulations for an individual-based model of chemotaxis of bacteria with internal dynamics. The variance reduction is achieved via a coupling of this model with a simpler process in which the internal dynamics has been replaced by a direct gradient sensing of the chemoattractants concentrations. In the companion paper cite{limits}, we have rigorously shown, using a pathwise probabilistic technique, that both processes converge towards the same advection-diffusion process in the diffusive asymptotics. In this work, a direct coupling is achieved between paths of individual bacteria simulated by both models, by using the same sets of random numbers in both simulations. This coupling is used to construct a hybrid scheme with reduced variance. We first compute a deterministic solution of the kinetic density description of the direct gradient sensing model; the deviations due to the presence of internal dynamics are then evaluated via the coupled individual-based simulations. We show that the resulting variance reduction is emph{asymptotic}, in the sense that, in the diffusive asymptotics, the difference between the two processes has a variance which vanishes according to the small parameter.

Full work available at URL: https://arxiv.org/abs/1111.5321

zbMATH Keywords

bacterial chemotaxisvelocity-jump processasymptotic variance reduction

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) General biology and biomathematics (92B05) Stochastic particle methods (65C35)

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