LTFHPlus
Software:5975932
CRANLTFHPlusMaRDI QIDQ5975932FDOQ5975932
Implementation of LT-FH++
Jette Steinbach, Emil Michael Pedersen, Florian Privé
Last update: 12 February 2024
Copyright license: GNU General Public License, version 3.0
Software version identifier: 2.1.1
Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <https://pure.au.dk/ws/portalfiles/portal/353346245/> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <https://www.nature.com/articles/s41467-023-41210-z> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.
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