BayesianMCPMod (Q5978527)
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Simulate, Evaluate, and Analyze Dose Finding Trials with Bayesian MCPMod
Language | Label | Description | Also known as |
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English | BayesianMCPMod |
Simulate, Evaluate, and Analyze Dose Finding Trials with Bayesian MCPMod |
Statements
Bayesian MCPMod (Fleischer et al. (2022) <doi:10.1002/pst.2193>) is an innovative method that improves the traditional MCPMod by systematically incorporating historical data, such as previous placebo group data. This R package offers functions for simulating, analyzing, and evaluating Bayesian MCPMod trials with normally distributed endpoints. It enables the assessment of trial designs incorporating historical data across various true dose-response relationships and sample sizes. Robust mixture prior distributions, such as those derived with the Meta-Analytic-Predictive approach (Schmidli et al. (2014) <doi:10.1111/biom.12242>), can be specified for each dose group. Resulting mixture posterior distributions are used in the Bayesian Multiple Comparison Procedure and modeling steps. The modeling step also includes a weighted model averaging approach (Pinheiro et al. (2014) <doi:10.1002/sim.6052>). Estimated dose-response relationships can be bootstrapped and visualized.
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8 January 2024
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