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CRANadestrMaRDI QIDQ5981704

Estimation in Optimal Adaptive Two-Stage Designs

Jan Meis

Last update: 27 September 2023

Copyright license: GNU General Public License, version 3.0, GNU General Public License, version 2.0

Software version identifier: 0.5.0

Description

Methods to evaluate the performance characteristics of various point and interval estimators for optimal adaptive two-stage designs. Specifically, this package is written to work with trial designs created by the 'adoptr' package (Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09>; Pilz et al. (2021) <doi:10.1002/sim.8953>)). Apart from the a priori evaluation of performance characteristics, this package also allows for the evaluation of the implemented estimators on real datasets, and it implements methods to calculate p-values.

Cites work

• The adoptr Package: Adaptive Optimal Designs for Clinical Trials in R
• Optimal planning of adaptive two‐stage designs

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