RsqMed

CRANRsqMedMaRDI QIDQ5980091

Total Mediation Effect Size Measure for High-Dimensional Mediators

Tianzhong Yang, Chunlin Li

Last update: 14 November 2023

Copyright license: GNU General Public License, version 3.0

Software version identifier: 0.1.7.1, 0.2.1.0, 1.1

Description

An implementation of calculating the R-squared measure as a total mediation effect size measure and its confidence interval for moderate- or high-dimensional mediator models. It gives an option to filter out non-mediators using variable selection methods. The original R package is directly related to the paper Yang et al (2021) "Estimation of mediation effect for high-dimensional omics mediators with application to the Framingham Heart Study" <doi:10.1101/774877>. The new version contains a choice of using cross-fitting, which is computationally faster. The details of the cross-fitting method are available in the paper Xu et al (2023) "Speeding up interval estimation for R2-based mediation effect of high-dimensional mediators via cross-fitting" <doi:10.1101/2023.02.06.527391>.

Cites work

• Estimation of Mediation Effect for High-dimensional Omics Mediators with Application to the Framingham Heart Study
• Speeding up interval estimation forR2-based mediation effect of high-dimensional mediators via cross-fitting*

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