Pharmacological dataset on drug-induced TdP risk assessment

DOI10.5281/zenodo.8058964Zenodo8058964MaRDI QIDQ4834866

Dataset published at Zenodo repository

MaRDI, Oleksandr Zadorozhnyi

Publication date: 20 June 2023

Copyright license: Creative Commons Attribution 4.0 International

Community: Graphical Modelling and Causal Inference

Description

A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset defines 4 torsade de pointes (TdP) risk categories in the parameter "class" . For each of 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained. Detailed description follows. A dash in the dataset means that no value was found publicly available, thus it was considered that the drug effect on that current was negligible. The dataset can be used (and is important) while studing causal discovery methods to infer ion channels selection for the drug-induced TdP risk.

Cites work

• In Silico Classifiers for the Assessment of Drug Proarrhythmicity

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