A Novel Causal Mediation Analysis Approach for Zero-Inflated Mediators (Q75444)
From MaRDI portal
scientific article from arXiv
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | A Novel Causal Mediation Analysis Approach for Zero-Inflated Mediators |
scientific article from arXiv |
Statements
24 January 2023
0 references
stat.AP
0 references
math.ST
0 references
stat.TH
0 references
This article explores the challenge of excessive zeros in white matter hyperintensities (WMH) counts, which is a significant issue for mediation analysis due to potential violations of statistical assumptions. To address this, researchers propose using ZILoN, ZINB, or ZIP distributions that can accommodate excess zeros and overdispersion. These distributions are chosen because they allow for flexible representation of the mediator's variability, considering factors contributing to its zero-inflated nature. The proposed method aims to provide a robust framework for estimating and testing mediation effects under the counterfactual outcomes framework, offering a comprehensive analysis of potential causal pathways affecting cognitive aging and neurodegenerative diseases related to WMH. (English)
0 references
In simpler terms, imagine your brain is like a computer with lots of files (memory) and connections (brain pathways). Some files might be empty (zeros), while others have useful information. The study looked at how these 'empty' or 'filled' parts of the memory affect how well you think and learn as you grow older. To do this, they used special brain scans to see if some areas were more filled with useful info than others, which could help understand problems like forgetfulness in old age or certain brain diseases. But there are many empty spaces (zeros) in these scan results, making it hard to study the effects properly. The scientists tried different ways to count and think about these zeros, using special math models that can handle lots of zeroes, so they could get a clearer picture of how memory works with age and what helps or hurts it. (English)
0 references
