nonlinear parameter estimation (uni uni reaction with product - Michaelis Menten model - steady state assumption)

Community: MathModDB

computational task	nonlinear task

Available identifiers

MaRDI QIDQ6684610

nonlinear fit to determine the limiting reaction rates and michaelis constants, named after Leonor Michaelis, Maud Menten

List of contained entities

Michaelis Menten equation (uni uni reaction with product - steady state assumption)	$v_{0} = \frac{\frac{V_{m a x, f}}{K_{S}} * c_{S} - \frac{V_{m a x, b}}{K_{P}} * c_{P}}{1 + \frac{c_{S}}{K_{S}} + \frac{c_{P}}{K_{P}}}$
	$K_{P}$ represents Michaelis constant product (uni uni reaction - steady state assumption)
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$V_{m a x, b}$ represents limiting reaction rate (uni uni reaction - backward)
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_{P}$ represents product concentration
	$c_{S}$ represents substrate concentration
	$v_{0}$ represents initial reaction rate

Michaelis constant product (uni uni reaction - steady state assumption)	$K_{P} \equiv \frac{k_{- 1} + k_{2}}{k_{- 2}}$	output
	$k_{- 1}$ represents reaction rate constant
	$k_{- 2}$ represents reaction rate constant
	$k_{2}$ represents reaction rate constant
	$K_{P}$ represents Michaelis constant product (uni uni reaction - steady state assumption)

Michaelis constant substrate (uni uni reaction - steady state assumption)	$K_{S} \equiv \frac{k_{- 1} + k_{2}}{k_{1}}$	output
	$k_{- 1}$ represents reaction rate constant
	$k_{1}$ represents reaction rate constant
	$k_{2}$ represents reaction rate constant
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)

initial reaction rate
limiting reaction rate (uni uni reaction - backward)	$V_{m a x, b} \equiv k_{- 2} c_{E_{0}}$	output
	$c_{E_{0}}$ represents enzyme concentration
	$k_{- 2}$ represents reaction rate constant
	$V_{m a x, b}$ represents limiting reaction rate (uni uni reaction - backward)

limiting reaction rate (uni uni reaction - forward)	$V_{m a x, f} \equiv k_{2} c_{E_{0}}$	output
	$c_{E_{0}}$ represents enzyme concentration
	$k_{2}$ represents reaction rate constant
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)

product concentration
substrate concentration

Further items linking to nonlinear parameter estimation (uni uni reaction with product - Michaelis Menten model - steady state assumption)

Item	Property
nonlinear parameter estimation of enzyme kinetics	specialized by
uni uni reaction (Michaelis Menten model with product - steady state assumption)	used by

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