Uni Uni Reaction with Competitive Partial Inhibition (Q6684687)

Enzyme (E) and Substrate (S) form an enzyme-substrate complex (ES), which catalyzes the formation of product (P). Rates for complex formation and dissociation are $k_{1}$ and $k_{-1}$, $k_{2}$ is the rate of the rate-determining enzymatic step of product formation. Free enzyme and the enzyme-substrate complex may bind an inhibitor (I) to form an enzyme-inhibitor (EI) and enzyme-inhibitor-substrate complex (EIS) with $k_{3}$ or $k_{-3}$ and $k_{4}$ or $k_{-4} as rates of inhibitor complex formation and depletion. Enzyme-inhibitor complex and enzyme-inhibitor-substrate convert into each other with rates $k_{5}$ and $k_{-5}$. From the enzyme-inhibitor-substrate complex product is formed with rate $k_{2}$. Properly this is a mixed partial inhibition in which the inhibitor does not affect the turnover rate,