uni uni reaction mixed partial inhibition (Michaelis Menten model without product - steady state assumption)

Community: MathModDB

deterministic model	mathematical model	nonlinear model	static model

Available identifiers

MaRDI QIDQ6675365

uni uni reaction Michaelis Menten model without product and mixed partial Inhibition via the steady state assumption, named after Leonor Michaelis, Maud Menten

List of contained entities

Michaelis Menten equation (uni uni reaction without product and mixed partial inhibition - steady state assumption)	$v_{0} = \frac{(V_{m a x, f} + \frac{V_{m a x, I, f} c_{I}}{K_{i u}}) c_{S}}{K_{S} (1 + \frac{c_{I}}{K_{i c}}) + (1 + \frac{c_{I}}{K_{i u}}) c_{S}}$
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{m a x, I, f}$ represents limiting reaction rate with inhibitor (uni uni reaction - forward)
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_{I}$ represents inhibitor concentration
	$c_{S}$ represents substrate concentration
	$v_{0}$ represents initial reaction rate

enzyme conservation	$c_{E_{0}} = c_{E} + c_{E X}$
	$c_{E X}$ represents complexed enzyme concentration
	$c_{E_{0}}$ represents enzyme concentration
	$c_{E}$ represents enzyme concentration

initial inhibitor concentration (uni uni reaction)	$c_{I} (t = 0) = c_{I_{0}}$	initial condition
	$c_{I}$ represents inhibitor concentration
	$t$ represents time

initial product concentration (uni uni reaction without product)	$c_{P} (t = 0) = 0$	initial condition
	$c_{P}$ represents product concentration
	$t$ represents time

initial substrate concentration (uni uni reaction)	$c_{S} (t = 0) = c_{S_{0}}$	initial condition
	$c_{S}$ represents substrate concentration
	$t$ represents time

law of mass action	$v = k \prod_{i = 1}^{n} c_{i}$
	$c_{i}$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate

mass balance	$δ_{t} + \nabla F = 0$
mixed enzyme inhibition coupling condition (uni uni reaction)	$K_{i c} \neq K_{i u}$	coupling condition
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)

uni uni reaction (Michaelis Menten model without product - steady state assumption)
uni uni reaction competitive partial inhibition (Michaelis Menten model without product - steady state assumption)
uni uni reaction uncompetitive partial inhibition (Michaelis Menten model without product - steady state assumption)

List of computational tasks

nonlinear parameter estimation (uni uni reaction without product and mixed partial inhibition - Michaelis Menten model - steady state assumption)

List of assumptions

steady state assumption

Described at:

Enzyme Kinetics	(review)

Further items linking to uni uni reaction mixed partial inhibition (Michaelis Menten model without product - steady state assumption)

Item	Property
initial reaction rate of uni uni reaction without product and mixed partial inhibition	modelled by
uni uni reaction (ODE model)	specialized by

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